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5-alpha-dihydrotestosterone elevations associated with phentermine use

机译：与芬特明的使用有关的5-α-二氢睾丸激素升高

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A case of 5-alpha-dihydrotestosterone (DHT) elevation associated with phentermine initiation is reported, and possible mechanisms are discussed. There are no published reports of this association in the literature. Clinical and laboratory information is described. A 72-year-old male with metastatic prostate cancer taking dutasteride to lower his DHT levels initiated phentermine 15 mg daily for weight loss. His DHT level drawn within 1 week prior to starting phentermine was 9.9 pg/ml. When reporting for follow up 2 weeks later, his DHT level had increased to 114 pg/ml. The DHT level was checked again 2 weeks after that visit, and had increased to 174 pg/ml. At that time, phentermine was discontinued, and 1 week later, the DHT level had decreased to 20.1 pg/ml. Over the next 4 months, the patient’s DHT levels were maintained at less than 20 pg/ml. Phentermine 15 mg daily was then reinitiated while his DHT level was 7.5 pg/ml. Two weeks after resuming phentermine, his DHT level had again increased to 196 pg/ml. The patient’s phentermine was then discontinued, and around 1 week later, his DHT level had fallen to 5.1 pg/ml. A 72-year-old male with metastatic prostate cancer experienced profound increases in DHT upon initiation of phentermine despite continuation of his baseline dutasteride therapy. The etiology of these increases is still unclear.
机译：报告了与芬特明启动相关的5-α-二氢睾酮（DHT）升高的情况，并讨论了可能的机制。文献中没有有关该协会的公开报道。描述了临床和实验室信息。一名患有转移性前列腺癌的72岁男性服用度他雄胺降低DHT水平，开始服用芬特明15毫克以减轻体重。在开始使用芬特明前1周内抽取的DHT为9.9 pg / ml。 2周后报告随访时，他的DHT水平已增至114 pg / ml。探视后2周再次检查DHT水平，并已升高至174 pg / ml。那时，停用芬特明，1周后，DHT水平降至20.1 pg / ml。在接下来的4个月中，患者的DHT水平保持在20 pg / ml以下。然后每天重新服用芬特明15 mg，而他的DHT水平为7.5 pg / ml。恢复芬特明后两周，他的DHT水平再次上升至196 pg / ml。然后停用患者的芬特明，大约1周后，他的DHT水平降至5.1 pg / ml。尽管开始他的基线度他雄胺治疗，但芬特明启动后，一名转移性前列腺癌的72岁男性的DHT明显升高。这些增加的病因尚不清楚。

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