...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Toxicology Research and Application >Acute-onset heart failure secondary to long-standing abuse of alcohol, cocaine, and marijuana: An instructive case and review of pathophysiology
【24h】

Acute-onset heart failure secondary to long-standing abuse of alcohol, cocaine, and marijuana: An instructive case and review of pathophysiology

机译：长期滥用酒精，可卡因和大麻引起的急性发作性心力衰竭：一个指导性案例和病理生理学回顾

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Acute-onset heart failure in a young, otherwise healthy patient can be due to either acquired or congenital etiologies. While some diagnoses carry specific histologic hallmarks, many causes of myocardial injury culminate in the relatively nonspecific morphologic pattern of dilated cardiomyopathy. In such cases, a broad differential diagnosis and close clinicopathologic correlation are essential. Here we describe the acute and chronic histologic features of heart failure arising in the context of long-standing abuse of cocaine, alcohol, and marijuana. The mechanisms of cardiotoxicity are discussed for each drug, with particular emphasis on the amplified cardiac injury caused by concomitant cocaine and alcohol use. Although its histologic features are themselves nonspecific, correlation with clinical history, targeted studies to exclude alternative diagnoses, and careful morphologic examination permit confident diagnosis of cardiomyopathy secondary to polysubstance abuse.
机译：年轻的，否则为健康的患者的急性发作性心力衰竭可能是由于获得性或先天性病因引起的。尽管某些诊断带有特定的组织学标志，但许多心肌损伤的原因最终导致扩张型心肌病的相对非特异性形态学模式。在这种情况下，广泛的鉴别诊断和紧密的临床病理相关性至关重要。在这里，我们描述了长期滥用可卡因，酒精和大麻引起的心力衰竭的急性和慢性组织学特征。讨论了每种药物的心脏毒性机制，特别强调了因同时使用可卡因和酒精引起的心脏放大损伤。尽管其组织学特征本身是非特异性的，但与临床病史相关，有针对性的研究排除了其他诊断，并且仔细的形态学检查可以确信诊断为多物质滥用继发的心肌病。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号