首页> 外文期刊>The Open Bioinformatics Journal >GraProStr - Graphs of Protein Structures: A Tool for Constructing the Graphs and Generating Graph Parameters for Protein Structures
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GraProStr - Graphs of Protein Structures: A Tool for Constructing the Graphs and Generating Graph Parameters for Protein Structures

机译:GraProStr-蛋白质结构图:构建蛋白质结构图和生成图参数的工具

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Protein structures can be represented as graphsetworks by defining the amino-acids as nodes and the noncovalentinteractions as connections (edges). An analysis of such a graph provides valuable insights into the globalstructural properties, function, folding, and stability of proteins. Here we have created a webtool GraProStr to generateprotein structure networks and analyze network parameters. Protein side-chain based, Cα/Cβ backbone based or proteinligandGraphs/Networks can be generated using GraProStr. The well tested tool is now made available to the scientificcommunity for the first time. GraProStr is available online and can be accessed fromhttp://vishgraph.mbu.iisc.ernet.in/GraProStr/index.html using any of the internet browsers (best viewed in Mozilla Firefoxversion ≥ 3.6). The webtool is written using Perl CGI and available using Apache Webserver. With its customizabledefinitions of protein structure networks and well defined network parameters, GraProStr can be a very useful tool forboth theoretical and experimental elucidation of protein structures.
机译:通过将氨基酸定义为节点,将非共价相互作用定义为连接(边),可以将蛋白质结构表示为图/网络。对这种图的分析为蛋白质的整体结构特性,功能,折叠和稳定性提供了宝贵的见解。在这里,我们创建了一个网络工具GraProStr来生成蛋白质结构网络并分析网络参数。可以使用GraProStr生成基于蛋白质侧链,基于Cα/Cβ主链或proteinligandGraphs / Networks的图像。经过良好测试的工具现已首次提供给科学界。 GraProStr可在线获得,并可使用任何Internet浏览器从http://vishgraph.mbu.iisc.ernet.in/GraProStr/index.html访问(最好在Mozilla Firefox版本≥3.6中查看)。该Webtool是使用Perl CGI编写的,并且可以通过Apache Webserver使用。凭借其可自定义的蛋白质结构网络定义和明确定义的网络参数,GraProStr可以成为非常有用的工具,可用于理论和实验阐明蛋白质结构。

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