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首页> 外文期刊>Translational Research in Oral Oncology >The motogenic effect of EGF and TGF-α on the migration of tumor cells from the oral region: A role of epithelial-to-mesenchymal transition in cancer and a route for translation into the clinic
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The motogenic effect of EGF and TGF-α on the migration of tumor cells from the oral region: A role of epithelial-to-mesenchymal transition in cancer and a route for translation into the clinic

机译：EGF和TGF-α的致癌作用对肿瘤细胞从口腔区域迁移的影响：上皮向间充质转化在癌症中的作用以及转化为临床的途径

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Aim:Epithelial-to-mesenchymal transition (EMT) is recognized as a hallmark of cancer. The change in phenotype of epithelial cells enables them to migrate and the cancer therefore, to become more aggressive. The presence of the epidermal growth factor receptor (EGFR) has been implicated in the spread and aggressive nature of oral tumors. The aims of this present study were to investigate the role of two different growth factors, both ligands of the receptor, and their influence on EMT and cellular motility.Methods:A number of assays were used to investigate the response of the cells to the two growth factors (EGF and transforming growth factor (TGF-α)). These techniques included the 2-D scratch assay, a 2-D-cell scatter assay, and immunocytochemistry. Normal keratinocytes (HaCaT), oral adenoid squamous cell carcinoma (TYS), and human salivary gland tumor cells were used in this study.Results:The results of the scratch and scatter assays indicated that EGF and TGF-α exerted differential effects upon the cel...
机译：目的：上皮向间质转化（EMT）被认为是癌症的标志。上皮细胞表型的变化使它们能够迁移，从而使癌症变得更具侵略性。表皮生长因子受体（EGFR）的存在与口腔肿瘤的扩散和侵袭性有关。本研究的目的是研究两种不同的生长因子（受体的两个配体）的作用，以及它们对EMT和细胞运动性的影响。方法：采用多种测定方法来研究细胞对两种生长因子的反应生长因子（EGF和转化生长因子（TGF-α））。这些技术包括二维刮擦测定，二维细胞散射测定和免疫细胞化学。本研究使用正常的角质形成细胞（HaCaT），口腔腺样鳞状细胞癌（TYS）和人唾液腺肿瘤细胞。结果：刮擦和散点分析的结果表明EGF和TGF-α对细胞产生了不同的作用。 ...

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