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首页> 外文期刊>Translational Research in Oral Oncology >Clinico-pathological prognosticators in oral squamous cell carcinoma: An update
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Clinico-pathological prognosticators in oral squamous cell carcinoma: An update

机译：口腔鳞状细胞癌的临床病理预后：最新进展

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Despite diagnostic and therapeutic advancements, mortality and morbidity rates in the patients diagnosed with oral cancer remain static. Hence, an understanding of the factors that predict the progression of oral cancer appears to be useful in deciding on the most appropriate therapy, thereby improving survival. To do so in practice, a critical knowledge of prognostic markers that have high sensitivity is essential. Though recent research has introduced newer molecular markers, challenging the conventional prognostic assessment methods their universal application is yet to be determined. In practice, clinical and histopathological parameters are widely used for the selection of treatment strategies and for the determination of prognosis in oral cancer patients. A literature search yielded a multitude of parameters to be involved in the determination of prognosis of a patient. Based on published evidence, factors of significance were pTNM, tumour volume, depth of invasion, surgical margin status, tumour budding, vascular and perineural invasion, medullary bone invasion, extracapsular spread and the presence of distant metastasis.
机译：尽管在诊断和治疗方面取得了进步，但诊断为口腔癌的患者的死亡率和发病率仍然保持不变。因此，了解预测口腔癌进展的因素似乎有助于决定最合适的治疗方法，从而提高生存率。为此，在实践中，具有高敏感性的预后标志物的关键知识至关重要。尽管最近的研究已经引入了更新的分子标记，但是挑战常规的预后评估方法及其普遍应用尚待确定。在实践中，临床和组织病理学参数被广泛用于治疗策略的选择和口腔癌患者预后的确定。文献检索得出了确定患者预后的众多参数。根据公开的证据，重要的因素是pTNM，肿瘤体积，浸润深度，手术切缘状态，肿瘤出芽，血管和神经周浸润，髓质骨浸润，囊外扩散和远处转移的存在。

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