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首页> 外文期刊>Translational Research in Oral Oncology >Perspectives on areca nut with some global implications: Symposium report:
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Perspectives on areca nut with some global implications: Symposium report:

机译：槟榔的观点对全球具有某些影响：专题报告：

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Areca nut and products made from the nut, evaluated by the International Agency for Research on Cancer as carcinogenic to humans since 2004, are being increasingly used in India and South East Asia and exported to many countries. There is thus an urgent need to identify best control policies and research gaps. On 1 February 2018, a group of experts shared their latest knowledge and perspectives on areca nut at Healis-Seksaria Institute for Public Health in Navi Mumbai, Maharashtra, India. By itself, areca nut has been implicated in oral and oesophageal cancer. Areca nut users are also at high risk of oral submucous fibrosis, a debilitating and potentially malignant condition. Users may also suffer adverse health outcomes due to smokeless tobacco, commonly mixed with areca nut. The use of areca nut commonly begins in childhood and often proceeds to use with tobacco. Gutka, a widely consumed, industrially made areca nut product containing tobacco, has been banned in all states and union territories of India, but it is still widely available. Areca nuts contain arecoline, an alkaloid that stimulates various brain receptors, promoting physical dependence. Areca nut alkaloids have also been implicated in carcinogenesis. Other chemicals, introduced during cultivation and processing of areca nuts, contribute to oral submucous fibrosis and cancer. The wide variety of products, different storage conditions and lack of regulation can lead to significant variation in the content of toxicants, carcinogens and alkaloids, making the psychological and physical dependence issues even more challenging. Regulation of product contents is needed as a part of control measures to supplement product bans.
机译：自2004年以来，国际癌症研究机构对槟榔和坚果制成的产品进行了评估，认为其对人类具有致癌性，在印度和东南亚越来越多地使用它们，并出口到许多国家。因此，迫切需要确定最佳控制策略和研究差距。 2018年2月1日，一群专家在印度马哈拉施特拉邦新孟买Healis-Seksaria公共卫生研究所分享了有关槟榔的最新知识和观点。就其本身而言，槟榔与口腔癌和食道癌有关。槟榔使用者也有口腔粘膜下纤维化的高风险，这是使人衰弱和潜在的恶性疾病。由于通常与槟榔混合使用的无烟烟草，使用者也可能遭受不利的健康后果。槟榔的使用通常始于儿童时期，并经常与烟草一起使用。古特卡是一种广泛消费的工业生产的含有烟草的槟榔产品，在印度的所有州和联合领地都被禁止使用，但仍很普及。槟榔包含槟榔碱，槟榔碱是一种生物碱，可刺激各种大脑受体，促进身体依赖性。槟榔生物碱也与致癌作用有关。在槟榔的种植和加工过程中引入的其他化学物质会导致口腔粘膜下纤维化和癌变。产品种类繁多，存储条件不同以及监管不力会导致毒物，致癌物和生物碱含量的显着变化，从而使心理和身体依赖性问题更具挑战性。需要对产品内容进行规定，作为补充产品禁令的控制措施的一部分。

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