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首页> 外文期刊>Translational Research in Oral Oncology >Evidence for chronic mechanical irritation as a causative factor in oral cancer: application of Bradford Hill criteria:
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Evidence for chronic mechanical irritation as a causative factor in oral cancer: application of Bradford Hill criteria:

机译：慢性机械刺激是口腔癌的病因的证据：Bradford Hill标准的应用：

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Chronic mechanical irritation (CMI) of the oral mucosa has been proposed as a risk factor for oral cancer (OC), but the available evidence is limited and controversial. One of the main limitations is the lack of proper criteria to define and classify CMI. The objective of this narrative review is to apply the Bradford Hill causality criteria to assess such an association based on the published literature. The level of evidence is not conclusive, mainly due to methodological shortcomings. Hence, to systematize future CMI research, we recommend the following items should be included: a clear definition for CMI, ascertaining any temporal association, recording all types of CMI: dental, prosthetic, and functional. Finally, it is important to emphasize that studies dealing with risk factors for OC should not only be restricted to established factors such as tobacco, alcohol, and areca nut consumption but should also consider other factors including the patient’s dental condition. In this regard, CMI, tooth loss, periodontal disease, and many others could be included. The causality criteria set out by Bradford Hill could be used for studying different controversial risk factors for OC.
机译：口腔粘膜的慢性机械刺激（CMI）已被提议为口腔癌（OC）的危险因素，但现有证据有限且存在争议。主要限制之一是缺乏定义和分类CMI的适当标准。本篇叙事评论的目的是应用Bradford Hill因果关系标准，根据已发表的文献评估这种关联。证据水平尚不确定，主要是由于方法上的缺陷。因此，为了系统化将来的CMI研究，我们建议应包括以下内容：CMI的明确定义，确定任何时间关联，记录所有类型的CMI：牙科，修复和功能性。最后，必须强调的是，有关OC危险因素的研究不仅应限于烟草，酒精和槟榔消费等既定因素，而且还应考虑其他因素，包括患者的牙齿状况。在这方面，可以包括CMI，牙齿脱落，牙周疾病和许多其他因素。布拉德福德·希尔（Bradford Hill）提出的因果关系标准可用于研究各种有争议的OC危险因素。

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