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首页> 外文期刊>Trakya Universitesi. Tip Fakultesi Dergisi. >Investigation of Monnose-Binding Lectin gene Polymorphism in Patients with Erythema Multiforme, Stevens-Johnson Syndrome and Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Overlap Syndrome
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Investigation of Monnose-Binding Lectin gene Polymorphism in Patients with Erythema Multiforme, Stevens-Johnson Syndrome and Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Overlap Syndrome

机译：多形性红斑，史蒂文斯-约翰逊综合症和史蒂文斯-约翰逊综合症/中毒性表皮坏死重叠综合征患者单糖结合凝集素基因多态性的研究

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Objective: Monnose-Binding lectin (MBL) appears to play an important role in the immune system. The genetic polymorphisms in the MBL2 gene can result in a reduction of serum levels, leading to a predisposition to recurrent infection. The aim of this study is to investigate the influence of a polymorphism in codon 54 of the MBL2 gene on the susceptibility to Erythema Multiforme, Stevens-Johnson Syndrome and Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Overlap Syndrome (EM, SJS and SJS/TEN overlap syndrome). Material and Methods: Our study included 64 patients who were clinically and/or histopathologically diagnosed with EM, SJS, and SJS/TEN overlap syndrome and 66 healthy control subjects who were genotyped for the MBL2 gene codon 54 polymorphism using the PCR-RFLP method. For all statistical analyses, the level of significance was set at p<0.05. Results: The prevalence of the B allele was 18% in the EM, SJS and SJS/TEN patient groups and 13% in the control group. No significant differences in allele frequencies of any polymorphism were observed between the patient and control groups, although the B allele was more frequent in the patient groups (p=0.328). Conclusion: Our results provide no evidence of a relationship between MBL2 gene codon 54 polymorphism and the susceptibility to EM, SJS and SJS/ TEN overlap syndrome. However, these findings should be confirmed in studies with a larger sample size.
机译：目的：结合猫的凝集素（MBL）在免疫系统中似乎起着重要的作用。 MBL2基因中的遗传多态性可导致血清水平降低，从而导致易复发感染。这项研究的目的是调查MBL2基因第54位密码子多态性对多形性红斑，史蒂文斯-约翰逊综合症和史蒂文斯-约翰逊综合症/毒性表皮坏死性重叠综合症（EM，SJS和SJS / TEN）的敏感性的影响重叠综合征）。材料和方法：我们的研究包括64例经临床和/或组织病理学诊断为EM，SJS和SJS / TEN重叠综合征的患者，以及66名健康对照受试者，他们使用PCR-RFLP方法对MBL2基因密码子54多态性进行了基因分型。对于所有统计分析，显着性水平设置为p <0.05。结果：EM，SJS和SJS / TEN患者组中B等位基因的患病率为18％，而对照组中为13％。患者和对照组之间没有观察到任何多态性的等位基因频率有显着差异，尽管在患者组中B等位基因更为频繁（p = 0.328）。结论：我们的结果没有提供证据表明MBL2基因密码子54多态性与EM，SJS和SJS / TEN重叠综合征的易感性之间存在关联。但是，这些发现应在样本量较大的研究中得到证实。

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