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>Analysis of the action mechanism of Fang Ji Huang Qi decoction in treating rheumatoid arthritis by network pharmacology
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Analysis of the action mechanism of Fang Ji Huang Qi decoction in treating rheumatoid arthritis by network pharmacology
Highlights The present study preliminarily verified the basic pharmacological action and its mechanism of Fang Ji Huang Qi decoction in the treatment of rheumatoid arthritis. Editor’s Summary The method of network pharmacology not only preliminarily demenstrated the use of Fang Ji Huang Qi decoction in the treatment of rheumatoid arthritis, but also suggested its potential application in the treatment of cancer. Objective To explore the pharmacological action mechanism of Fang Ji Huang Qi decoction (FHD) in the treatment of rheumatoid arthritis (RA) by network pharmacology. Methods The chemical compositions and functional targets of the TCM were retrieved using the systematic pharmacological analysis platform TCMSP, and the gene name of each target protein was obtained from the UniProtKB network platform. The targets of RA were queried through the CTD database. The protein-protein interaction network was constructed in the STRING database, and the network visualization analysis was performed in Cytoscape. The Gene Ontology and Kyoto Gene and Genomic Encyclopedia pathways enrichment analyses of key target proteins were performed using the DAVID data platform. Results A total of 472 drug active ingredients were screened from the TCMSP database. Seventy-five disease targets from the CTD database were screened. The compound-target network map contained further screened out 98 components and corresponding 75 targets. The key compounds included quercetin and kaempferol. The key targets were prostaglandin G/H synthase 2 and nitric oxide synthase 2. The protein-protein interaction network consisted of 75 proteins, of which 37 were key proteins, including tumor protein 53, JUN and interleukin-6. There were 260 Gene Ontology entries, of which 246 were biological processes. Fifty-five Kyoto Gene and Genomic Encyclopedia pathways were enriched, mainly the cancer pathway, NOD-like receptor signaling pathway, and Toll-like receptor signaling pathway, which are involved in the action mechanism of FHD. Conclusion The results of this study preliminarily verified the basic pharmacological action mechanism of FHD in the treatment of RA, laying a foundation for elucidating its mechanism of action.
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