• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Translational psychiatry. >Deep brain stimulation for treatment-resistant major depressive disorder: a comparison of two targets and long-term follow-up
【24h】

Deep brain stimulation for treatment-resistant major depressive disorder: a comparison of two targets and long-term follow-up

机译：深度脑刺激治疗难治性重度抑郁症：两个靶点的比较和长期随访

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We previously found that electrical stimulation in the anterior limb of the internal capsule/bed nucleus of the stria terminalis (IC/BST) alleviates depressive symptoms in severe treatment-resistant obsessive-compulsive disorder (OCD) patients. Here we tested the hypothesis that electrical stimulation in either IC/BST or in the inferior thalamic peduncle (ITP) effectively reduces depressive symptoms in treatment-resistant major depressive disorder (TRD). In a double-blind crossover design, the effects of electrical stimulation at both targets were compared in TRD patients. The 17-item Hamilton Depression Rating scale (HAM-D) was the primary outcome measure. During the first crossover, patients received IC/BST stimulation versus no stimulation in random order (2 × 1 weeks). During the second crossover (3 × 2 months), patients received IC/BST versus ITP versus no stimulation. Patients and evaluators were blinded for stimulation conditions. All patients ( n =7) were followed up for at least 3 years (3–8 years) after implantation. Six patients completed the first crossover and five patients completed the second. During the first crossover, mean (s.d.) HAM-D scores were 21.5 (2.7) for no stimulation and 11.5 (8.8) for IC/BST stimulation. During the second crossover, HAM-D scores were 15.4 (7.5) for no stimulation, 7.6 (3.8) for IC/BST stimulation and 11.2 (7.5) for ITP stimulation. The final sample size was too small to statistically analyze this second crossover. At last follow-up, only one patient preferred ITP over IC/BST stimulation. Two patients, with a history of suicide attempts before implantation, committed suicide during the follow-up phases of this study. Our data indicate that, in the long term, both ITP and IC/BST stimulation may alleviate depressive symptoms in patients suffering from TRD.
机译：我们先前发现，电刺激末端纹状体的内囊/床核前肢（IC / BST）可缓解重度难治性强迫症（OCD）患者的抑郁症状。在这里，我们测试了以下假设：在IC / BST或丘脑下蒂（ITP）中进行电刺激可有效减轻对治疗有抵抗力的严重抑郁症（TRD）的抑郁症状。在双盲交叉设计中，在TRD患者中比较了两个目标的电刺激效果。 17项汉密尔顿抑郁量表（HAM-D）是主要的结局指标。在第一次分频中，患者随机接受IC / BST刺激，而无刺激（2×1周）。在第二次分频（3×2个月）期间，患者接受IC / BST与ITP的对比，而无刺激。患者和评估者对刺激条件视而不见。所有患者（n = 7）在植入后均接受了至少3年（3-8年）的随访。六名患者完成了第一次交叉，五名患者完成了第二次交叉。在第一次交叉测试中，无刺激的HAM-D平均（s.d.）得分为21.5（2.7），IC / BST刺激的平均HAM-D得分为11.5（8.8）。在第二次转换中，无刺激的HAM-D得分为15.4（7.5），IC / BST刺激的HAM-D得分为7.6（3.8），ITP刺激的HAM-D得分为11.2（7.5）。最终样本量太小，无法对第二次交叉进行统计分析。在最后一次随访中，只有一名患者更喜欢ITP，而不是IC / BST刺激。两名在植入前曾尝试自杀的患者在本研究的后续阶段自杀。我们的数据表明，长期来看，ITP和IC / BST刺激均可减轻TRD患者的抑郁症状。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号