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Serendipity in search for longevity from experiences of Hansen people

机译：从汉森人的经历中寻找长寿

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While surveying Korean centenarians, I had a fortune to encounter Hansen people, who spent long lives in the restricted sanatorium for leprosy patients. Their unexpectedly long life span compared with the normal population prompted me to examine the background and possible mechanism. Interestingly, a considerable number of these people maintain their intake of 4, 4′-diaminodiphenyl sulfone (DDS), a therapeutic drug for leprosy, habitually for more than three or four decades despite being completely cured of the disease. They have a higher antioxidant activity in their blood than age-matched controls. The protective function of DDS against oxidative stress was confirmed by in?vitro tests and in?vivo animal models. Moreover, DDS extended life span and increased mobility in a nematode model by inhibiting pyruvate kinase. When DDS effect on functional loss of the older people's muscles was tested, its anti-sarcopenia effect was prominent, especially in non-dominant muscles of DDS-consuming Hansen people. Concerning neurodegenerative disorders, DDS is significantly protective in animal model against Parkinson's disease. Taken together, DDS, serendipitously discovered in the Korean centenarian study, might be a candidate as a new therapeutic modality for protection against aging-dependent dysfunction in neural and muscular degeneration, and possibly for extension of lifespan.
机译：在调查韩国百岁老人时，我很幸运地遇到了汉森人，他们在麻风病患者的受限疗养院里度过了长寿。与正常人群相比，它们的寿命异常长，促使我检查了背景和可能的机制。有趣的是，尽管这种疾病已完全治愈，但仍有相当数量的人习惯摄入三，四，十年以上的4、4'-二氨基二苯砜（DDS），这是一种用于麻风的治疗药物。他们的血液中的抗氧化活性比年龄匹配的对照组更高。体外试验和体内动物模型证实了DDS对氧化应激的保护作用。此外，DDS通过抑制丙酮酸激酶延长了线虫模型的寿命并增加了其活动性。当测试DDS对老年人肌肉功能丧失的作用时，其抗肌肉减少症的作用尤为突出，特别是在消耗DDS的汉森人的非优势肌肉中。关于神经退行性疾病，DDS在动物模型中对帕金森氏病具有明显的保护作用。综上所述，在韩国百岁老人研究中偶然发现的DDS可能会成为一种新的治疗方法，以预防神经和肌肉变性引起的衰老依赖性功能障碍，并可能延长寿命。

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