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首页> 外文期刊>Translational psychiatry. >You say ‘prefrontal cortex’ and I say ‘anterior cingulate’: meta-analysis of spatial overlap in amygdala-to-prefrontal connectivity and internalizing symptomology
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You say ‘prefrontal cortex’ and I say ‘anterior cingulate’: meta-analysis of spatial overlap in amygdala-to-prefrontal connectivity and internalizing symptomology

机译：您说的是“前额叶皮层”，我说的是“前扣带回”：杏仁核到前额叶连接性和内在症状的空间重叠的元分析

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Connections between the amygdala and medial prefrontal cortex (mPFC) are considered critical for the expression and regulation of emotional behavior. Abnormalities in frontoamygdala circuitry are reported across several internalizing conditions and associated risk factors (for example, childhood trauma), which may underlie the strong phenotypic overlap and co-occurrence of internalizing conditions. However, it is unclear if these findings converge on the same localized areas of mPFC or adjacent anterior cingulate cortex (ACC). Examining 46 resting-state functional connectivity magnetic resonance imaging studies of internalizing conditions or risk factors (for example, early adversity and family history), we conducted an activation likelihood estimation meta-analysis of frontoamygdala circuitry. We included all reported amygdala to frontal coordinate locations that fell within a liberal anatomically defined frontal mask. Peak effects across studies were centered in two focal subareas of the ACC: pregenual (pgACC) and subgenual (sgACC). Using publicly available maps and databases of healthy individuals, we found that observed subareas have unique connectivity profiles, patterns of neural co-activation across a range of neuropsychological tasks, and distribution of tasks spanning various behavioral domains within peak regions, also known as ‘functional fingerprints’. These results suggest disruptions in unique amygdala–ACC subcircuits across internalizing, genetic and environmental risk studies. Based on functional characterizations and the studies contributing to each peak, observed amygdala–ACC subcircuits may reflect separate transdiagnostic neural signatures. In particular, they may reflect common neurobiological substrates involved in developmental risk (sgACC), or the broad expression of emotional psychopathology (pgACC) across disease boundaries.
机译：杏仁核和内侧前额叶皮层（mPFC）之间的连接被认为对情绪行为的表达和调节至关重要。据报道，在几种内在化状况和相关的危险因素（例如，儿童期创伤）中，前额杏仁核回路异常，这可能是内在化状况强烈的表型重叠和共同发生的基础。但是，尚不清楚这些发现是否收敛于mPFC的相同局部区域或相邻的前扣带回皮质（ACC）。通过检查46种内在条件或危险因素（例如，早期逆境和家族病史）的静息状态功能连通性磁共振成像研究，我们对额叶杏仁扁桃体回路进行了激活可能性估算荟萃分析。我们将所有报道的杏仁核纳入了在解剖学上定义的额叶面罩内的额叶坐标位置。整个研究的峰值效应集中在ACC的两个焦点子区域：先天性（pgACC）和次要性（sgACC）。使用公众可获得的健康个体的地图和数据库，我们发现观察到的子区域具有独特的连通性概况，跨一系列神经心理学任务的神经共激活模式以及跨峰区域内各个行为域的任务分布，也称为“功能性”指纹”。这些结果表明，在内部化，遗传和环境风险研究中，独特的杏仁核–ACC子回路受到破坏。基于功能特征和对每个峰都有贡献的研究，观察到的杏仁核–ACC子电路可能反映了单独的经诊断神经信号。特别是，它们可能反映了涉及发育风险（sgACC）或情绪性精神病理学（pgACC）跨疾病边界的广泛表达的常见神经生物学底物。

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