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首页> 外文期刊>Translational Research in Oral Oncology >Human papillomavirus DNA prevalence and type distribution in oral squamous cell carcinoma in Ghana:
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Human papillomavirus DNA prevalence and type distribution in oral squamous cell carcinoma in Ghana:

机译：加纳口腔鳞状细胞癌中人乳头瘤病毒DNA的流行和类型分布：

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Objective:To determine the prevalence of human papillomavirus (HPV) DNA in oral squamous cell carcinoma (OSCC).Methods:A total of 88 OSCC specimens collected between 2006 and 2013 were available for the study. DNA was extracted using formalin-fixed, paraffin-embedded specimens and analysed for the presence of 18 HPV genotypes using a nested polymerase chain reaction using consensus forward primer (GP-E6-3F) and two consensus back primers (GP-E7-5B and GP-E7-6B). Plasmid DNA of HPV 16 and 18 was used as positive controls.Results:HPV DNA was detected in 3 of the 88 samples, a prevalence of 3.4%. Genotypes detected were 16, 18 and 52.Conclusion:The overall prevalence of HPV DNA was 3.4%. Only high-risk genotypes were detected. This low prevalence of high-risk types of HPV suggests that the HPV virus may not have a significant role in the development of oral cancers in Ghana, unlike higher rates described elsewhere in the world, especially in Western countries. Surveillance of future prevalence of HPV and att...
机译：目的：确定人乳头瘤病毒（HPV）DNA在口腔鳞状细胞癌（OSCC）中的流行程度。方法：2006-2013年间共收集了88份OSCC标本。使用福尔马林固定，石蜡包埋的标本提取DNA，并使用共有正向引物（GP-E6-3F）和两个共有反向引物（GP-E7-5B和A）通过巢式聚合酶链反应分析18种HPV基因型的存在。 GP-E7-6B）。 HPV 16和18的质粒DNA被用作阳性对照。结果：在88份样本中有3份检测到HPV DNA，患病率为3.4％。检测到的基因型分别为16、18和52。结论：HPV DNA的总体患病率为3.4％。仅检测到高风险的基因型。高危型HPV的这种低流行表明，在加纳，HPV病毒可能在口腔癌的发生中没有重要作用，这与世界其他地方，尤其是西方国家所描述的更高的发病率不同。监测HPV的未来流行和感染情况

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