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首页> 外文期刊>Translational Developmental Psychiatry >Effects of Acute Tryptophan Depletion Moja-De on Behavioral Inhibition in Healthy Adults
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Effects of Acute Tryptophan Depletion Moja-De on Behavioral Inhibition in Healthy Adults

机译：急性色氨酸耗竭Moja-De对健康成年人行为抑制的影响

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BackgroundAlterations in serotonergic (5-HT) neurotransmission are thought to play a decisive role in affective disorders and impulse control. However, the studies on the involvement of cerebral 5-HT availability and its effects on behavioral inhibition in healthy subjects yielded inconsistent findings. It appears that central nervous serotonergic neurotransmission is rather related to context-specific aspects of suppression of behavior than motor response inhibition alone. Crockett et al. aimed to disentangle the involvement of 5-HT on aspects of motor response inhibition, punishment-induced suppression of inappropriate responses, and sensitivity toward aversive outcomes in a single behavioral Go-NoGo task using a fixed dosage acute tryptophan depletion (ATD) procedure. While motor response inhibition was unaffected, punishmentinduced inhibition was reported to be abolished by ATD.ObjectiveA recently developed refined and body-weight-adjusted ATD protocol (Moja-De) was applied. We aimed to replicate the experiment of Crockett et al. using a Go-NoGo task in a comparable sample of young healthy adults.MethodsCentral nervous 5-HT synthesis was lowered by administering a body-weight-adapted ATD procedure in a randomized, double-blind, within-subject, repeated measures design in 24 healthy volunteers. A tryptophan-balanced amino acid beverage served as a control condition. The above-mentioned Go-NoGo task was administered 180 minutes after beverage intake. Blood samples were obtained at four time points: baseline, 90 minutes, 180 minutes, and 270 minutes after beverage administration.ResultsATD produced significant depletion of plasma levels of both total and free tryptophan at all post-ATD time points, compared with a balanced amino acid load (BAL). While overall Go-NoGo performance accuracy was not affected by ATD, response times significantly decreased. Also, the ability to adjust behavioral responding in regard to aversive outcome magnitude and behavioral adjustments following error contingent punishment remain intact after decreased brain 5-HT synthesis. However, no dissociation effect of ATD on punishment-induced inhibition was observed.ConclusionOur study using a recently developed refined and individually adjusted tryptophan depletion procedure assessed with the identical behavioral task as used by Crockett et al. yielded challenging results compared with the original study in terms of the role of 5-HT in behavioral inhibition. Our findings suggest that ATD Moja-De facilitates adequate responding (improved response times) at equally low performance accuracy, compared with BAL. ATD-specific reductions in punishment-induced inhibition were not observed in the present sample, thus challenging the suggested role of 5-HT related to the aversive context of inhibitory behavior in the original study. Overall, our results suggest that body weight adjusted Moja-De trypthophan depletion does not result in disruptions of punishment related behavioral functioning. The use of a more refined and individually adjusted depletion procedure might, at least in part, explain the discrepancies between the two studies.
机译：背景血清素能（5-HT）神经传递的改变被认为在情感障碍和冲动控制中起决定性作用。但是，有关健康受试者大脑5-HT可用性及其对行为抑制的影响的研究结果不一致。看来中枢神经血清素神经传递与行为抑制的上下文特定方面有关，而不是与单独的运动反应抑制有关。 Crockett等。旨在通过固定剂量的急性色氨酸耗竭（ATD）程序，消除5-HT在运动反应抑制，惩罚诱导的不适当反应抑制以及对厌恶结果敏感性方面的参与。虽然运动反应抑制不受影响，但据报道ATD消除了惩罚性诱导的抑制。目的采用最近开发的改良和体重调整的ATD方案（Moja-De）。我们旨在复制Crockett等人的实验。方法在24名患者中通过随机，双盲，受试者内重复测量的方法采用适应体重的ATD程序降低中枢神经5-HT合成水平健康的志愿者。色氨酸平衡的氨基酸饮料用作对照条件。饮料摄入后180分钟执行上述Go-NoGo任务。饮料给药后的四个时间点（基线，90分钟，180分钟和270分钟）采集血样。结果与平衡氨基酸相比，ATD在所有ATD后的时间点都显着消耗了总色氨酸和游离色氨酸的血浆水平。酸负荷（BAL）。虽然整体Go-NoGo性能准确性不受ATD的影响，但响应时间显着减少。同样，在减少脑5-HT合成后，可以调整与厌恶性结果幅度有关的行为反应能力，并在错误或有惩罚之后进行行为调整。然而，没有观察到ATD对惩罚诱导的抑制具有解离作用。结论我们的研究使用了最近开发的，经过精细调整和单独调整的色氨酸耗竭程序，并与Crockett等人使用的行为任务相同。就5-HT在行为抑制中的作用而言，与原始研究相比，产生了具有挑战性的结果。我们的发现表明，与BAL相比，ATD Moja-De可以在同样低的性能精度下促进足够的响应（改进的响应时间）。在本样本中未观察到ATD特异性降低惩罚诱导的抑制作用，因此挑​​战了5-HT在原始研究中与抑制行为的厌恶环境有关的建议作用。总体而言，我们的结果表明，体重调整的Moja-De色氨酸的消耗不会导致与惩罚相关的行为功能的破坏。使用更精细和单独调整的耗竭程序至少可以部分解释这两项研究之间的差异。

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