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首页> 外文期刊>Tropical Journal of Pharmaceutical Research >Anti-hypertensive effect of Gastrodia elata Bl leaf extract in rats
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Anti-hypertensive effect of Gastrodia elata Bl leaf extract in rats

机译：天麻B1叶提取物对大鼠的降压作用

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Purpose: To investigate the probable antihypertensive effects of Gastrodia elata Bl. extract (GEBE) in renovascular hypertensive rats as well as the mechanism involved in blood pressure reduction. Methods: The two-kidney one-clip (2K1C) Goldblatt model of renovascular hypertension was used in Wistar rats. The 2K1C group rats were treated with captopril (40 mg/kg/day), low-dose GEBE (150 mg/kg/day) and high-dose of GEBE (300 mg/kg/day) for 6 weeks by intragastric administration. Systolic (SBP) and diastolic blood pressure (DBP) were measured by the tail-cuff method. Urine creatinine and urea levels of the rats were measured by enzyme-linked immunosorbent assay (ELISA). Superoxide dismutase (SOD) and malondialdehyde (MDA) levels were also evaluated. Results: In the captopril- and GEBE-treated groups, blood pressure decreased progressively over the course of the 6-week treatment period compared with that of the untreated (control) rats (p 0.01). High-dose GEBE also significantly increased plasma SOD activity but decreased plasma MDA concentration (p 0.05). Renal function improved following captopril and GEBE (300 mg/kg/day) treatment (p 0.01). Conclusion: The results suggest that GEBE probably exerts an antihypertensive effect by inhibiting endothelin (ET)-converting enzyme and via its antioxidant activity.
机译：目的：探讨天麻的降压作用。肾血管性高血压大鼠中的提取物（GEBE）以及涉及血压降低的机制。方法：在Wistar大鼠中使用两肾一夹（2K1C）Goldblatt肾血管性高血压模型。 2K1C组大鼠通过胃内给药分别用卡托普利（40 mg / kg /天），低剂量GEBE（150 mg / kg /天）和高剂量GEBE（300 mg / kg /天）治疗6周。通过尾袖法测量收缩压（SBP）和舒张压（DBP）。通过酶联免疫吸附测定（ELISA）测量大鼠的尿肌酐和尿素水平。还评估了超氧化物歧化酶（SOD）和丙二醛（MDA）的水平。结果：在卡托普利和GEBE治疗组中，与未治疗（对照组）大鼠相比，在6周的治疗过程中血压逐渐降低（p <0.01）。大剂量GEBE还显着增加了血浆SOD活性，但降低了血浆MDA浓度（p <0.05）。卡托普利和GEBE（300 mg / kg /天）治疗后，肾功能得到改善（p <0.01）。结论：结果表明，GEBE可能通过抑制内皮素（ET）转化酶并通过其抗氧化活性发挥降压作用。

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