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首页> 外文期刊>Tropical Journal of Pharmaceutical Research >Prognostic implications of plasma fibrinogen and serum C-reactive protein levels in non-small cell lung cancer resection and survival
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Prognostic implications of plasma fibrinogen and serum C-reactive protein levels in non-small cell lung cancer resection and survival

机译：血浆纤维蛋白原和血清C反应蛋白水平在非小细胞肺癌切除和生存中的预后意义

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Purpose: To investigate the prognostic implications of plasma fibrinogen and serum C-reactive protein (CRP) levels in tumour resection and survival following successful tumour resection in patients with non-small cell lung cancer (NSCLC). Methods: One hundred and fifty-three NSCLC patients who underwent surgical resection at a tertiary care hospital from January 2006 through December 2010 were enrolled. Pre-operative serum CRP and plasma fibrinogen levels were measured. The levels of these biomarkers correlated with tumour size and pathologic TNM stage. The possibility of complete resection and associated findings are reported. Results: Plasma fibrinogen (r = 0.381, p = 0.002) and serum CRP (r = 0.471, p 0.001) levels were positively associated with tumour diameter. Increased levels of these biomarkers were significantly associated with sex, smoking status, histological type, tumour stage, and clinical stage. Partial tumour resection occurred in 28 % (27/95) of patients with an increased plasma fibrinogen level compared to 10 % (6/58) with a normal fibrinogen level (p = 0.008), and in 30 % (29/97) of patients with an increased serum CRP level compared to 11 % (6/56) with a normal CRP level (p = 0.006). Patients with elevated CRP and fibrinogen concentrations demonstrated higher susceptibility to disease advancement and survival compared to patients with normal fibrinogen and CRP levels. Conclusion: Pre-operative functional concentrations of serum CRP and plasma fibrinogen could serve as indicators of tumour resectability wherein a high tumour resection rate is possible in patients with favourable pre-operative levels of these biomarkers. Increased concentrations of serum CRP and plasma fibrinogen are associated with poor overall survival and progression-free survival.
机译：目的：研究血浆纤维蛋白原和血清C反应蛋白（CRP）水平在非小细胞肺癌（NSCLC）患者成功切除肿瘤后的肿瘤切除和存活中的预后意义。方法：纳入2006年1月至2010年12月在三级医院接受外科手术切除的NSCLC患者153例。测量术前血清CRP和血浆纤维蛋白原水平。这些生物标志物的水平与肿瘤大小和病理性TNM分期相关。报告了完全切除的可能性和相关的发现。结果：血浆纤维蛋白原（r = 0.381，p = 0.002）和血清CRP（r = 0.471，p <0.001）水平与肿瘤直径呈正相关。这些生物标志物水平的增加与性别，吸烟状况，组织学类型，肿瘤分期和临床分期显着相关。血浆纤维蛋白原水平升高的患者中28％（27/95）发生部分肿瘤切除，而纤维蛋白原水平正常（p = 0.008）的患者为10​​％（6/58），而血浆纤维蛋白原水平为30％（29/97）的患者血清CRP水平升高的患者，而CRP水平正常的患者为11％（6/56）（p = 0.006）。与具有正常纤维蛋白原和CRP水平的患者相比，具有较高CRP和纤维蛋白原浓度的患者对疾病进展和生存的敏感性更高。结论：术前血清CRP和血浆纤维蛋白原的功能浓度可作为肿瘤可切除性的指标，在​​这些生物标记物具有良好的术前水平的患者中，可能有较高的肿瘤切除率。血清CRP和血浆纤维蛋白原浓度升高与总体生存率低和无进展生存期相关。

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