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首页> 外文期刊>Tropical Journal of Pharmaceutical Research >Analgesic, anti-inflammatory and immuno-modulatory effects of dezocine-propofol anesthesia combination following colonoscopy
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Analgesic, anti-inflammatory and immuno-modulatory effects of dezocine-propofol anesthesia combination following colonoscopy

机译：结肠镜检查后地佐辛-丙泊酚麻醉联合的镇痛，抗炎和免疫调节作用

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Purpose: To study and compare the analgesic, anti-inflammatory and immuno-modulatory effects of dezocine-propofol, and fentanyl-propofol combinations in colonoscopy. Methods: One hundred and thirty-four patients who received painless colonoscopy in Eastern Medical District of Linyi People's Hospital, Linyi City, Shandong Province, China, from June 2013 to December 2016 were randomly divided into two groups. Patients in the observation group (aged 42 - 65 years) received dezocine-propofol combination as anesthesia, while those in the control group (aged 41 - 67 years) were anesthetized with fentanyl-propofol. Serum levels of pain and inflammatory mediators, as well as contents of immune response molecules were determined prior to, during and after colonoscopy using either enzyme-linked immunosorbent assay (ELISA) or electro-chemiluminescence kits. Results: There were no statistically significant differences in the serum levels of 5-hydroxytryptophan (5-HTP), 5-hydroxy indole acetic acid (5-HIAA), substance P (SP), prostaglandin E2 (PGE2), C-reactive protein (CRP), heat shock protein 70 (HSP70), Interleukin-1 β(IL-1β), adrenocorticotropic hormone (ACTH), Cortisol (Cor), Inositol (Ins), c-peptide (C-P), immunoglobulin G (IgG) and immunoglobulin A (IgA), complement 3 (C3) and complement 4 (C4) before and during colonoscopy between the two groups of patients. However, after the examination, serum levels of 5-HTP, 5-HIAA, SP, PGE2, CRP, HSP70, IL-1 beta, ACTH, Cor, Ins and C-P in the observation group were significantly lower than those in control group (p 0.05), while IgG, IgA, C3 and C4 contents were significantly higher than those of the control group (p 0.05). Conclusion: These results suggest that the analgesic effect of dezocine-propofol combination after colonoscopy examination is superior to that of fentanyl-propofol combination, due to its effectiveness in inhibiting inflammatory reactions and improving immune response.
机译：目的：在结肠镜检查中研究和比较地佐辛-丙泊酚和芬太尼-丙泊酚组合的镇痛，抗炎和免疫调节作用。方法：2013年6月至2016年12月，在山东省临沂市临沂市人民医院东部医学区接受无痛结肠镜检查的134例患者随机分为两组。观察组（42-65岁）的患者接受地佐辛-丙泊酚联合麻醉，而对照组（41-67岁）的患者则用芬太尼-丙泊酚麻醉。在结肠镜检查之前，期间和之后，使用酶联免疫吸附测定（ELISA）或电化学发光试剂盒测定血清中的疼痛和炎症介质水平以及免疫应答分子的含量。结果：血清5-羟色氨酸（5-HTP），5-羟吲哚乙酸（5-HIAA），P物质（SP），前列腺素E2（PGE2），C反应蛋白水平无统计学差异。 （CRP），热休克蛋白70（HSP70），白介素-1β（IL-1β），促肾上腺皮质激素（ACTH），皮质醇（Cor），肌醇（Ins），c肽（CP），免疫球蛋白G（IgG）两组患者在结肠镜检查之前和期间进行免疫球蛋白A（IgA），补体3（C3）和补体4（C4）检测。然而，检查后，观察组的5-HTP，5-HIAA，SP，PGE2，CRP，HSP70，IL-1 beta，ACTH，Cor，Ins和CP的血清水平显着低于对照组（ p <0.05），而IgG，IgA，C3和C4含量显着高于对照组（p <0.05）。结论：这些结果表明，结肠镜检查后的地佐辛-丙泊酚组合的镇痛效果优于芬太尼-丙泊酚组合，因为它具有抑制炎症反应和改善免疫反应的功效。

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