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首页> 外文期刊>Turkish Journal of Veterinary and Animal Sciences >Single intramuscular administration of long-acting oxytetracycline in grouper (Epinephelus marginatus)
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Single intramuscular administration of long-acting oxytetracycline in grouper (Epinephelus marginatus)

机译：石斑鱼（长鳍pine鱼）中的长效土霉素单次肌内给药

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摘要

The plasma concentration of long-acting oxytetracycline (OTC-LA) was measured following a single intramuscular (IM) injection (50 mg/kg) in grouper (Epinephelus marginatus), a common inhabitant of marine aquaria and a potential candidate for fish farming. The experiment was carried out at 20 ?°C and sampling points were selected at 0.25, 0.5, 1, 2, 4, 6, 8, 12, 24, and 48 h post-administration. OTC concentration in grouper circulation was maintained at high levels for the whole experiment (8.35-39.67 mug/mL) with maximum plasma concentration measured at 1 h post-injection. The area under the curve values was also promising since AUC0-24 and AUC 0-48 were calculated to be high (363.45 and 668.73 mug h/mL, respectively). Due to the high OTC levels accomplished for prolonged period of time, a single administration of OTC-LA could be an ideal route in cases when multiple handling is unwanted and big animals such as grouper are to be treated.
机译：长效土霉素（OTC-LA）的血浆浓度是在石斑鱼（Epinephelus marginatus），海洋水族箱的常见种群和可能进行养鱼的单一肌内（IM）注射（50 mg / kg）后进行测量的。实验在20°C下进行，在给药后0.25、0.5、1、2、4、6、8、12、24和48 h选择采样点。在整个实验中，石斑鱼循环中的OTC浓度保持在较高水平（8.35-39.67 mug / mL），注射后1 h测得最大血浆浓度。曲线值下的面积也很有希望，因为计算得出的AUC0-24和AUC 0-48较高（分别为363.45和668.73 mug h / mL）。由于长时间要达到较高的OTC水平，如果不希望进行多次处理并且需要处理大型动物（例如石斑鱼），则一次施用OTC-LA可能是理想的途径。

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