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首页> 外文期刊>Turkish Journal of Veterinary and Animal Sciences >Genetic analysis of avian paramyxovirus type I strains isolated from backyard poultry in Iran
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Genetic analysis of avian paramyxovirus type I strains isolated from backyard poultry in Iran

机译：从伊朗后院家禽分离的I型禽副粘病毒株的遗传分析

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Newcastle disease (ND) is one of the most serious diseases amongst many species of birds and causes huge economic losses in the poultry sector. Backyard poultry are the main source of food in rural areas of many developing countries and play a crucial role in the epidemiology of ND. The sequence of the F protein cleavage site is the major virulence determinant of Newcastle disease virus (NDV). The aim of this study was to understand the molecular characterization of F proteins of Iranian backyard poultry in NDVs. The complete open reading frame sequences of the F gene of six isolates were amplified and sequenced. All characterized NDVs had high similarities to Chinese isolates. The phylogenetic analysis revealed that the studied strains fell into genotype VII and grouped in a specific subgenotype. All tested NDVs have a cleavage site of 112RRQKRF↓117, representing that all of them belonged to velogenic strains. Rearing methods of backyard poultry increase the chance of contact between a variety of poultry and wild birds; subsequently, new strains evolve and are transmitted between them. Therefore, continuous monitoring of NDVs in backyard poultry would help us to obtain more information about the evolution of NDVs and improve new control strategies in backyard poultry.
机译：新城疫（ND）是许多鸟类中最严重的疾病之一，并在家禽业造成巨大的经济损失。后院家禽是许多发展中国家农村地区的主要食物来源，并且在ND的流行病学中起着至关重要的作用。 F蛋白切割位点的序列是新城疫病毒（NDV）的主要毒力决定因素。这项研究的目的是了解NDV中伊朗后院家禽F蛋白的分子特征。扩增并测序了六个分离株F基因的完整阅读框序列。所有特征性的NDV与中国分离株具有高度相似性。系统发育分析表明，所研究的菌株属于基因型VII，并分组为特定的亚基因型。所有测试的NDV都有一个 112 RRQKRF ↓117 的切割位点，表明它们都属于速溶菌株。后院家禽的饲养方法增加了各种家禽与野禽接触的机会;随后，新的毒株进化并在它们之间传播。因此，持续监测后院家禽中的NDVs将有助于我们获得有关NDVs进化的更多信息，并改善后院家禽的新控制策略。

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