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首页> 外文期刊>Turkish Journal of Veterinary and Animal Sciences >Investigation of the efficiency and safety of tilmicosin phosphate in treating experimental mycoplasmal infections in pigs
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Investigation of the efficiency and safety of tilmicosin phosphate in treating experimental mycoplasmal infections in pigs

机译：磷酸替米考星治疗猪实验性支原体感染的有效性和安全性研究

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摘要

In order to evaluate the in vivo therapeutic effect of oral administration of tilmicosin phosphate on mycoplasmal pneumonia in swine and its safety for the infected swine, the model of mycoplasmal pneumonia disease in swine was established by artificial infection, and indices such as efficiency, cure rate, death rate, the score of lung lesion, and the routine blood tests, blood biochemistry, and routine urine tests of tested swine were determined. The results showed that all of the dosage groups of 100 mg/L, 80 mg/L, 60 mg/L of 10% tilmicosin phosphate soluble powder demonstrated distinct therapeutic effects on mycoplasmal pneumonia in pigs, significantly reducing the scores of lung lesions in diseased pigs, and that the treatment effect of 60-80 mg/L tilmicosin phosphate soluble powder was equivalent to that of 10% tilmicosin soluble powder. Administration of 10% tilmicosin phosphate soluble powder improved the weight gain of the diseased swine. Treatment of infected pigs with 60?100 mg/L of 10% tilmicosin phosphate soluble powder did not seem to influence the routine blood tests, biochemical index, and routine urine tests, and is therefore safe for diseased swine. In conclusion, administration of 10% tilmicosin phosphate soluble powder is effective and safe to treat artificially infected swine with mycoplasmal pneumonia.
机译：为了评价口服磷酸替米考星对猪支原体肺炎的体内治疗效果及其对猪的安全性，通过人工感染建立了猪支原体肺炎的模型，并评价了效率，治愈率等指标。测定被测猪的死亡率，死亡率，肺病变评分以及常规血液检查，血液生化和尿常规检查。结果表明，所有剂量组分别为100 mg / L，80 mg / L，60 mg / L的10％磷酸替米考星可溶性粉，对猪的支原体肺炎表现出独特的治疗作用，显着降低了患病肺部病变的评分猪，并且60-80 mg / L磷酸替米考星可溶性粉的治疗效果与10％替米考星可溶性粉的治疗效果相当。施用10％磷酸替米考星可溶性粉改善了患病猪的体重增加。用60？100 mg / L的10％磷酸替米考星可溶性粉治疗感染猪似乎没有影响常规的血液检查，生化指标和常规的尿液检查，因此对于患病的猪是安全的。总之，施用10％磷酸替米考星可溶性粉对支原体肺炎人工感染的猪是有效和安全的。

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