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首页> 外文期刊>Turkish Journal of Veterinary and Animal Sciences >The effects of three different prokinetic drugs on the motility hormones level in lambs with postoperative ileus
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The effects of three different prokinetic drugs on the motility hormones level in lambs with postoperative ileus

机译：三种促运动药物对肠梗阻羔羊运动激素水平的影响

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The aim of this study was to evaluate the effects of the three different prokinetic agents, namely erythromycin, lidocaine, and metoclopramide in lambs with postoperative ileus (POI) using motilin and ghrelin, which are known as motility markers. Twenty lambs were allocated to 4 groups of 5 lambs each. An enterotomy was performed on the ileum of each lamb. Erythromycin (8.8 mg/kg), metoclopramide (0.2 mg/kg), and saline (2 mL) were administered as single dose IM before surgery in the ERT, MET, and CNTR groups, respectively. Lidocaine was administered to the LID group, both as a bolus before (1.3 mg/kg IV) and as a continuous rate infusion during surgery (0.05 mg/kg/h IV). Serum motilin and ghrelin concentrations as motility hormones were measured with ELISA. The serum motilin concentration was significantly higher at 0, 1, 3, 5, 10, 24, and 48 h in the ERT group and at 1 and 10 h in the LID group. The serum ghrelin concentration was significantly higher at 0, 1, and 48 h in the ERT group and at 3, 5, 10, 24, and 48 h in the LID group. As a result, erythromycin and lidocaine was thought to be useful in lambs with POI according to the stimulatory effects on the motility hormones.
机译：这项研究的目的是使用动蛋白和生长素释放肽（胃动素）评估三种不同的促运动剂，即红霉素，利多卡因和胃复安对术后肠梗阻（POI）羔羊的影响。将20只羊羔分配给4组，每组5只羊羔。对每只羔羊的回肠进行肠切开术。 ERT，MET和CNTR组分别在手术前以单剂量IM施用红霉素（8.8 mg / kg），胃复安（0.2 mg / kg）和生理盐水（2 mL）。利多卡因在LID组之前以推注方式给药（1.3 mg / kg IV），在手术过程中以连续速率输注（0.05 mg / kg / h IV）。用ELISA测量血清胃动蛋白和生长素释放肽的浓度，作为运动激素。 ERT组分别在0、1、3、5、10、24和48 h以及LID组在1和10 h的血清胃动蛋白浓度显着升高。 ERT组分别在0、1、48小时和LID组分别在3、5、10、24和48小时时，血清生长素释放肽浓度显着升高。结果，根据对运动激素的刺激作用，红霉素和利多卡因被认为对POI羔羊有用。

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