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首页> 外文期刊>Trials >Benefits and side effects of blood pressure lowering treatment: what was wrong with doxazosin in the ALLHAT?
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Benefits and side effects of blood pressure lowering treatment: what was wrong with doxazosin in the ALLHAT?

机译：降压治疗的益处和副作用：多沙唑嗪在ALLHAT中出了什么问题？

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The lowering of high blood pressure is supposed to protect target organs from hypertensive damage. The Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial was designed to compare the cardioprotective properties of three antihypertensives from different classes (lisinopril, amlodipine and doxazosin) with chlorthalidone. Despite effective blood pressure lowering and a favorable metabolic profile, the doxazosin arm of the trial had a significantly higher relative risk of cardiovascular disease and heart failure compared with the chlorthalidone arm. This article speculates on possible causes for this unexpected result and suggests that the culprit may be accentuation of the vascular effects of vasopressin, which are maximized under α-adrenergic blockade. These findings may have implications for the large number of older men who receive monotherapy with α-blockers for treatment of prostatic symptoms.
机译：高血压的降低被认为可以保护靶器官免受高血压损害。旨在预防心脏病的降压和降脂治疗试验旨在比较三种不同类别的降压药（赖诺普利，氨氯地平和多沙唑嗪）与氯噻酮的心脏保护作用。尽管有效降低了血压并改善了代谢，该试验的多沙唑嗪组与氯噻酮组相比，心血管疾病和心力衰竭的相对风险明显更高。本文推测了导致这种意想不到的结果的可能原因，并指出罪魁祸首可能是由于血管加压素的血管作用增强，在α-肾上腺素能阻滞下最大程度地发挥了作用。这些发现可能对大量接受α受体阻滞剂单一疗法治疗前列腺症状的老年男性有影响。

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