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首页> 外文期刊>Trials >Transcranial magnetic stimulation for tinnitus: using the Tinnitus Functional Index to predict benefit in a randomized controlled trial
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Transcranial magnetic stimulation for tinnitus: using the Tinnitus Functional Index to predict benefit in a randomized controlled trial

机译：经颅磁刺激耳鸣：使用耳鸣功能指数预测随机对照试验的获益

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Background Identifying characteristics associated with transcranial magnetic stimulation (TMS) benefit would offer insight as to why some individuals experience tinnitus relief following TMS treatment, whereas others do not. The purpose of this study was to use the Tinnitus Functional Index (TFI) and its subscales to identify specific factors associated with TMS treatment responsiveness. Methods Individuals with bothersome tinnitus underwent 2000 pulses of 1-Hz TMS for 10 consecutive business days. The primary outcome measure was the TFI which yields a total score and eight individual subscale scores. Analyses were performed on baseline data from the active arm ( n =?35) of a prospective, double-blind, randomized placebo-controlled clinical trial of TMS for tinnitus. Results Baseline total TFI score and three of the eight TFI subscales were useful in differentiating between responders and nonresponders to TMS intervention for tinnitus. These findings are not definitive, but suggest potential factors that contribute to perceived benefit following TMS. Conclusions Overall, the main factor associated with TMS benefit was a higher tinnitus severity score for responders at baseline. The TFI subscales helped to clarify the factors that contributed to a higher severity score at baseline. Large-scale prospective research using systematic approaches is needed to identify and describe additional factors associated with tinnitus benefit following TMS. Trial registration ClinicalTrials.gov, ID: NCT01104207 . Registered on 13 April 2010.
机译：背景识别与经颅磁刺激（TMS）益处相关的特征将提供有关为什么有些人在TMS治疗后出现耳鸣缓解而其他人则没有的见解。这项研究的目的是使用耳鸣功能指数（TFI）及其子量表来确定与TMS治疗反应性相关的特定因素。方法患有耳鸣的患者连续10个工作日接受2000次1-Hz TMS脉冲。主要结局指标是TFI，可得出总分和8个单独的子量表得分。对来自TMS的一项前瞻性，双盲，随机安慰剂对照临床试验的活动组（n = 35）的基线数据进行了分析。结果基线总TFI评分和八个TFI分量表中的三个有助于区分对耳鸣的TMS干预的反应者和非反应者。这些发现不是确定的，但是提示了潜在的因素，这些因素有助于TMS带来知觉的益处。结论总体而言，与TMS获益相关的主要因素是基线时应答者的耳鸣严重度评分较高。 TFI分量表有助于阐明导致基线严重程度评分较高的因素。需要使用系统的方法进行大规模的前瞻性研究，以识别和描述与TMS后耳鸣获益相关的其他因素。试用注册ClinicalTrials.gov，ID：NCT01104207。 2010年4月13日注册。

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