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首页> 外文期刊>Trials >Postprandial effect of breakfast glycaemic index on vascular function, glycaemic control and cognitive performance (BGI study): study protocol for a randomised crossover trial
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Postprandial effect of breakfast glycaemic index on vascular function, glycaemic control and cognitive performance (BGI study): study protocol for a randomised crossover trial

机译：餐后血糖指数对餐后血管功能，血糖控制和认知能力的影响（BGI研究）：一项随机交叉试验的研究方案

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Background Postprandial glycaemic response affects cognitive and vascular function. The acute effect of breakfast glycaemic index on vascular parameters is not sufficiently known. Also, the influence of breakfasts with different glycaemic index on cognitive performance has been mostly studied in children and adolescents with varying results. Therefore, the purpose of this study is to analyse the postprandial effect of high and low glycaemic index breakfasts on vascular function and cognitive performance and their relationship with postprandial glycaemic response in healthy young adults. Methods/design This is a crossover clinical trial targeting adults (aged 20–40 years, free from cardiovascular disease) selected by consecutive sampling at urban primary care health clinics in Salamanca (Spain). Each subject will complete three interventions with a washout period of one week: a control condition (consisting of water); a low glycaemic index breakfast (consisting of dark chocolate, walnuts, yogurt and an apple, with an overall glycaemic index of 29.4 and an energy contribution of 1489?kJ); and a high glycaemic index breakfast (consisting of bread, grape juice and strawberry jam, with an overall glycaemic index of 64.0 and an energy contribution of 1318?kJ). The postprandial effect will be assessed at 60 and 120?minutes from each breakfast including blood sampling and cognitive performance evaluations. Measurements of arterial stiffness and central haemodynamic parameters will be taken at –10, 0, 15, 30, 45, 60, 75, 90, 105 and 120?minutes. Discussion The differences in postprandial glycaemic response due to breakfast glycaemic index could affect vascular parameters and cognitive performance with important applications and implications for the general population. This could provide necessary information for the establishment of new strategies in terms of nutritional education and work performance improvement. Trial registration ClinicalTrials.gov: ? NCT02616276 ?. Registered on 19 November 2015.
机译：背景餐后血糖反应影响认知和血管功能。早餐血糖指数对血管参数的急性影响尚不清楚。此外，大多数儿童和青少年研究了不同血糖指数的早餐对认知能力的影响，结果各不相同。因此，本研究的目的是分析健康年轻人中高和低血糖指数早餐对餐后血管功能和认知功能的影响及其与餐后血糖反应的关系。方法/设计这是一项针对成年人（20至40岁，无心血管疾病）的交叉临床试验，通过在西班牙萨拉曼卡（Salamanca）的城市初级保健诊所进行连续抽样选择。每个受试者将完成三个干预，干预期为一个星期：控制条件（由水组成）;低血糖指数早餐（由黑巧克力，核桃，酸奶和苹果组成，总血糖指数为29.4，能量贡献为1489？kJ）;以及高血糖指数的早餐（由面包，葡萄汁和草莓果酱组成，总血糖指数为64.0，能量贡献为1318？kJ）。餐后效果将在每次早餐后60分钟和120分钟进行评估，包括采血和认知能力评估。动脉僵硬度和中央血液动力学参数的测量将在–10、0、15、30、45、60、75、90、105和120分钟进行。讨论早餐血糖指数导致的餐后血糖反应差异可能影响血管参数和认知表现，对重要人群具有重要的应用和意义。这可以为制定有关营养教育和改善工作绩效的新战略提供必要的信息。试用注册ClinicalTrials.gov： NCT02616276？ 2015年11月19日注册。

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