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首页> 外文期刊>Trials >Counteracting Age-related Loss of Skeletal Muscle Mass: a clinical and ethnological trial on the role of protein supplementation and training load (CALM Intervention Study): study protocol for a randomized controlled trial
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Counteracting Age-related Loss of Skeletal Muscle Mass: a clinical and ethnological trial on the role of protein supplementation and training load (CALM Intervention Study): study protocol for a randomized controlled trial

机译：抵消与年龄有关的骨骼肌重量损失：蛋白质补充和训练负荷作用的临床和人种学试验（CALM干预研究）：一项随机对照试验的研究方案

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Background Aging is associated with decreased muscle mass and functional capacity, which in turn decrease quality of life. The number of citizens over the age of 65?years in the Western world will increase by 50 % over the next four decades, and this demographic shift brings forth new challenges at both societal and individual levels. Only a few longitudinal studies have been reported, but whey protein supplementation seems to improve muscle mass and function, and its combination with heavy strength training appears even more effective. However, heavy resistance training may reduce adherence to training, thereby attenuating the overall benefits of training. We hypothesize that light load resistance training is more efficient when both adherence and physical improvement are considered longitudinally. We launched the interdisciplinary project on Counteracting Age-related Loss of Skeletal Muscle Mass (CALM) to investigate the impact of lifestyle changes on physical and functional outcomes as well as everyday practices and habits in a qualitative context. Methods We will randomize 205 participants older than 65?years to be given 1?year of two daily nutrient supplements with 10?g of sucrose and 20?g of either collagen protein, carbohydrates, or whey. Further, two groups will perform either heavy progressive resistance training or light load training on top of the whey supplement. Discussion The primary outcome of the CALM Intervention Study is the change in thigh cross-sectional area. Moreover, we will evaluate changes in physical performance, muscle fiber type and acute anabolic response to whey protein ingestion, sensory adaptation, gut microbiome, and a range of other measures, combined with questionnaires on life quality and qualitative interviews with selected subjects. The CALM Intervention Study will generate scientific evidence and recommendations to counteract age-related loss of skeletal muscle mass in elderly individuals. Trial registration ClinicalTrials.gov NCT02034760 . Registered on 10 January 2014. ClinicalTrials.gov NCT02115698 . Registered on 14 April 2014. Danish regional committee of the Capital Region H-4-2013-070. Registered on 4 July 2013. Danish Data Protection Agency 2012-58-0004 – BBH-2015-001 I-Suite 03432. Registered on 9 January 2015.
机译：背景衰老与肌肉质量和功能能力下降有关，继而降低生活质量。在未来的40年中，西方国家65岁以上的公民数量将增加50％，而这一人口变化给社会和个人带来了新的挑战。仅报道了一些纵向研究，但是乳清蛋白补充剂似乎可以改善肌肉质量和功能，并且将其与沉重的力量训练相结合似乎更为有效。但是，沉重的阻力训练可能会降低对训练的依从性，从而削弱了训练的整体效益。我们假设在纵向上同时考虑坚持和身体改善时，轻负荷阻力训练更为有效。我们发起了一项跨学科项目，以“抗击与年龄有关的骨骼肌质量损失”（CALM），以定性的方式研究生活方式改变对身体和功能结局以及日常实践和习惯的影响。方法我们将205名年龄在65岁以上的参与者随机分配给他们，给予1年1次的每日两次营养补充剂，其中包括10微克蔗糖和20微克胶原蛋白，碳水化合物或乳清。此外，两组将在乳清补充剂的基础上进行沉重的渐进性阻力训练或轻负荷训练。讨论CALM干预研究的主要结果是大腿横截面积的变化。此外，我们将结合生活质量调查表和对选定对象的定性访谈，评估其身体表现，肌纤维类型和对乳清蛋白摄入，合成适应性，肠道微生物组以及其他一系列措施的急性合成代谢反应的变化。 CALM干预研究将产生科学证据和建议，以抵消老年患者与年龄相关的骨骼肌质量损失。试用注册ClinicalTrials.gov NCT02034760。 2014年1月10日注册。ClinicalTrials.gov NCT02115698。 2014年4月14日注册。首都地区丹麦区域委员会H-4-2013-070。 2013年7月4日注册。丹麦数据保护局2012-58-0004 – BBH-2015-001 I-Suite03432。2015年1月9日注册。

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