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首页> 外文期刊>Vascular Health and Risk Management >Individual patient-data meta-analysis comparing clinical outcome in patients with ST-elevation myocardial nfarction treated with percutaneous coronary intervention with or without prior thrombectomy. ATTEMPT study: A pooled Analysis of Trials on ThrombEctomy in acute Myocardial infarction based on individual PatienT data
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Individual patient-data meta-analysis comparing clinical outcome in patients with ST-elevation myocardial nfarction treated with percutaneous coronary intervention with or without prior thrombectomy. ATTEMPT study: A pooled Analysis of Trials on ThrombEctomy in acute Myocardial infarction based on individual PatienT data

机译：个别患者数据荟萃分析比较了经皮冠状动脉介入治疗或未行血栓切除术治疗的ST段抬高型心肌梗死患者的临床结局。 ATTEMPT研究：基于个人PatienT数据的急性心肌梗塞血栓切除术试验汇总分析

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Background: Available data from randomized trials on thrombectomy in patients with ST-elevation myocardial infarction (STEMI) have shown favorable trends in myocardial reperfusion. However, few data are available on the effect of thrombectomy on clinical outcome. Thus we have designed a collaborative individual patient-data meta-analysis which aimed to assess the long-term clinical outcome in STEMI patients randomized to percutaneous coronary intervention (PCI) with or without thrombectomy. Method: After a thorough database search, the principal investigators of randomized trials comparing thrombectomy with standard PCI in patients with STEMI were contacted. Principal investigators as authors of 11 randomized studies agreed to participate and were asked to complete a structured database by providing a series of key pre-PCI clinical and angiographic data as well as the longest available clinical outcome of the patients enrolled in the corresponding trial. The primary end-point of this pooled analysis is the comparison of overall survival rates between patients randomized to PCI with thrombectomy or PCI without thrombectomy. The secondary end-points are survival free from myocardial infarction (MI), target lesion revascularization (TLR), major adverse coronary events (MACE: death + MI + TLR) and death + MI between patients randomized to PCI with thrombectomy or PCI without thrombectomy. A pre-defined subgroup analysis is planned considering the following variables: type of thrombectomy device used, diabetes, rescue PCI, IIb/IIIa-inhibitors use, time-to-reperfusion, infarct-related artery, and pre-PCI TIMI flow. Implications: This study will provide useful data on the effect of the reported improved myocardial perfusion associated with thrombectomy on the long-term clinical outcome in patients with STEMI.
机译：背景：ST抬高型心肌梗死（STEMI）患者的血栓切除术随机试验的可用数据显示了心肌再灌注的有利趋势。但是，鲜有关于血栓切除术对临床结果影响的数据。因此，我们设计了一项协作的个人患者数据荟萃分析，旨在评估随机接受经皮冠状动脉介入治疗（PCI）或不行血栓切除术的STEMI患者的长期临床疗效。方法：经过彻底的数据库搜索后，与随机对照试验的主要研究人员进行了联系，该试验比较了STEMI患者的血栓切除术与标准PCI的比较。作为11项随机研究的作者的主要研究人员同意参加，并被要求通过提供一系列关键的PCI前临床和血管造影数据以及参加该试验的患者可获得的最长临床结果来完成结构化数据库。这项汇总分析的主要终点是比较接受随机血栓切除术的PCI患者或不进行血栓切除术的PCI患者的总生存率。次要终点是无血栓切除术或无血栓切除术的PCI患者之间无心肌梗死（MI），靶病变血运重建（TLR），主要不良冠脉事件（MACE：死亡+ MI + TLR）和死亡+ MI的生存率。 。考虑以下变量，计划进行预定义的亚组分析：使用的血栓切除设备类型，糖尿病，抢救PCI，使用IIb / IIIa抑制剂，再灌注时间，梗塞相关动脉和PCI前TIMI流量。启示：这项研究将为已报道的血栓切除术改善的心肌灌注对STEMI患者的长期临床结果的影响提供有用的数据。

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