...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Tropical Medicine and Health >Dengue virus receptor
【24h】

Dengue virus receptor

机译：登革热病毒受体

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Dengue virus is an arthropod-borne virus transmitted by Aedes mosquitoes. Dengue virus causes fever and hemorrhagic disorders in humans and non-human primates. Direct interaction of the virus introduced by a mosquito bite with host receptor molecule(s) is crucial for virus propagation and the pathological progression of dengue diseases. Therefore, elucidation of the molecular mechanisms underlying the interaction between dengue virus and its receptor(s) in both humans and mosquitoes is essential for an understanding of dengue pathology. In addition, understanding the molecular mechanism(s) of virus entry is crucial for the development of effective new therapies to treat dengue patients. Binding of dengue virus to its receptor molecules is mediated through a viral envelope glycoprotein, termed E protein. We present a summary and describe the structures, binding properties, and pathological relevance of dengue virus receptor molecules proposed to date. In mammalian cells, there are many candidate molecules that may act as receptors, such as sulfated glycosaminoglycans (GAGs), lectins that recognize carbohydrates, glycosphingolipid (GSL), proteins with chaperone activity, laminin-binding proteins, and other uncharacterized proteins. There are also several lines of evidence for receptor molecules such as GSLs, proteins with chaperone activity, laminin-binding proteins, and other uncharacterized proteins in mosquito cells and organs. This review focuses on several molecules involved in carbohydrate-dependent binding of the virus.
机译：登革热病毒是由伊蚊传播的节肢动物传播的病毒。登革热病毒在人类和非人类灵长类动物中引起发烧和出血性疾病。蚊子叮咬引入的病毒与宿主受体分子的直接相互作用对于病毒传播和登革热疾病的病理进展至关重要。因此，阐明人类和蚊子中登革热病毒及其受体之间相互作用的分子机制对于理解登革热病理至关重要。另外，了解病毒进入的分子机制对于开发有效的治疗登革热患者的新疗法至关重要。登革热病毒与其受体分子的结合通过称为E蛋白的病毒包膜糖蛋白介导。我们提出了一个摘要，并描述了迄今为止提出的登革热病毒受体分子的结构，结合特性和病理相关性。在哺乳动物细胞中，有许多可能充当受体的候选分子，例如硫酸化糖胺聚糖（GAG），识别碳水化合物的凝集素，鞘糖脂（GSL），具有伴侣活性的蛋白，层粘连蛋白结合蛋白和其他未表征的蛋白。对于蚊子细胞和器官中的受体分子，例如GSL，具有伴侣活性的蛋白，层粘连蛋白结合蛋白和其他未表征的蛋白，也有多种证据。这篇综述着重于与病毒的碳水化合物依赖性结合有关的几种分子。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号