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首页> 外文期刊>Vascular Health and Risk Management >Effect of lipopenic and hypotensive treatment on homocysteine levels in type 2 diabetics
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Effect of lipopenic and hypotensive treatment on homocysteine levels in type 2 diabetics

机译：降脂和降压治疗对2型糖尿病患者同型半胱氨酸水平的影响

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Aim: Evaluate the effect of lipopenic and hypotensive treatment on homocysteine levels. Methods: We recruited 145 type 2 diabetics and 130 control subjects. Thirty-seven diabetics had no complications, 54 had microvascular complications and 54 had macrovascular complications. We determined the parameters homocysteine of lipid, vitamin B12, triglycerides, and folates for all subjects. Associated treatments used one or more of the following drugs, statin, fibrate, angiotensin-converting enzyme inhibitor and beta-blockers. Results: Hyperhomocysteinemia was present in 35.6% of patients. Diabetics had elevated serum levels of triglycerides ( P < 0.001), homocysteine ( P < 0.01), folates ( P < 0.01) and vitamin B12 ( P < 0.001). A strong association was found between type 2 diabetes and hyperhomocysteinemia ( P < 0.001). Diabetics with associated treatment had elevated homocysteine, vitamin B12 and folate levels when compared to diabetes-free controls. For diabetics with macrovascular complications, we found significant differences in homocysteine ( P = 0.010) and folate ( P = 0.014) between those taking associated drugs and those who did not. For diabetics with microvascular complications, a significant difference was found in folate only ( P = 0.012). Conclusion: Drugs used for hypertension and hyperlipidemia may have an effect on homocysteine levels, for this reason the interaction between drug action and homocysteine levels should be taken into consideration.
机译：目的：评估降脂和降压治疗对同型半胱氨酸水平的影响。方法：我们招募了145名2型糖尿病患者和130名对照受试者。 37例糖尿病患者无并发症，54例患有微血管并发症，54例患有大血管并发症。我们确定了所有受试者的脂质，维生素B12，甘油三酸酯和叶酸的同型半胱氨酸参数。相关治疗使用了以下一种或多种药物：他汀类药物，贝特类药物，血管紧张素转化酶抑制剂和β受体阻滞剂。结果：高同型半胱氨酸血症存在于35.6％的患者中。糖尿病患者的甘油三酸酯（P <0.001），高半胱氨酸（P <0.01），叶酸（P <0.01）和维生素B12（P <0.001）的血清水平升高。发现2型糖尿病与高同型半胱氨酸血症之间有很强的相关性（P <0.001）。与无糖尿病对照相比，进行相关治疗的糖尿病患者高半胱氨酸，维生素B12和叶酸水平升高。对于有大血管并发症的糖尿病患者，我们发现服用相关药物的人和未服用相关药物的人的高半胱氨酸（P = 0.010）和叶酸（P = 0.014）存在显着差异。对于具有微血管并发症的糖尿病患者，仅叶酸存在显着差异（P = 0.012）。结论：用于高血压和高脂血症的药物可能对同型半胱氨酸水平有影响，因此应考虑药物作用与同型半胱氨酸水平之间的相互作用。

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