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BCG Vaccination in HIV-Infected Children

机译:艾滋病毒感染儿童的卡介苗接种

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摘要

Despite the use of Bacillus Calmette-Guérin (BCG) vaccination for many years, infants and young children exposed to adults with infectious forms of tuberculosis (TB) are at high risk of developing complicated TB disease. This risk is much higher among HIV-infected children, and data on BCG protective efficacy in HIV-infected children is lacking. Recent research on BCG safety in HIV-infected infants has resulted in policy shifts, but implementation is challenging. New approaches to preventing TB among infants and children, particularly HIV-infected infants, are needed. This paper briefly reviews BCG safety and efficacy considerations in HIV-infected infants and discusses other approaches to preventing TB, including new TB vaccines and vaccination strategies.
机译:尽管已经使用卡介苗芽孢杆菌(BCG)疫苗进行了多年疫苗接种,但暴露于具有传染性结核病(TB)的成人的婴幼儿仍很容易患上复杂的结核病。在感染HIV的儿童中,这种风险要高得多,并且缺乏关于在感染HIV的儿童中BCG保护功效的数据。最近对艾滋病毒感染婴儿的卡介苗安全性的研究导致了政策的转变,但实施工作具有挑战性。需要新的预防婴儿和儿童尤其是HIV感染婴儿的结核病的方法。本文简要回顾了卡介苗在感染艾滋病毒的婴儿中的安全性和有效性,并讨论了其他预防结核病的方法,包括新的结核病疫苗和疫苗接种策略。

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