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Lactoferrin Augmentation of the BCG Vaccine Leads to Increased Pulmonary Integrity

机译：卡介苗疫苗的乳铁蛋白增强导致肺完整性增强

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The goal of vaccination to prevent tuberculosis disease (TB) is to offer long-term protection to the individual and the community. In addition, the success of any protective TB vaccine should include the ability to limit cavitary formation and disease progression. The current BCG vaccine protects against disseminated TB disease in children by promoting development of antigenic-specific responses. However, its efficacy is limited in preventing postprimary pulmonary disease in adults that is responsible for the majority of disease and transmission. This paper illustrates the use of lactoferrin as an adjuvant to boost efficacy of the BCG vaccine to control organism growth and limit severe manifestation of pulmonary disease. This resulting limitation in pathology may ultimately, limit spread of bacilli and subsequent transmission of organisms between individuals. The current literature is reviewed, and data is presented to support molecular mechanisms underlying lactoferrin's utility as an adjuvant for the BCG vaccine.
机译：预防结核病（TB）疫苗的目标是为个人和社区提供长期保护。此外，任何保护性结核疫苗的成功都应包括限制空洞形成和疾病进展的能力。当前的BCG疫苗通过促进抗原特异性反应的发展来预防儿童传播的结核病。但是，它在预防成人原发性肺部疾病（主要是疾病和传播途径）方面的功效有限。本文阐述了乳铁蛋白作为佐剂的使用，以增强卡介苗疫苗控制生物体生长和限制肺部疾病严重表现的功效。这种导致的病理学限制最终可能会限制细菌的传播以及随后个体之间生物的传播。目前的文献进行了审查，并提供数据来支持乳铁蛋白作为BCG疫苗佐剂的实用性的分子机制。

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