...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Tuberculosis Research and Treatment >Stratified Threshold Values of QuantiFERON Assay for Diagnosing Tuberculosis Infection in Immunocompromised Populations
【24h】

Stratified Threshold Values of QuantiFERON Assay for Diagnosing Tuberculosis Infection in Immunocompromised Populations

机译：QuantiFERON分析的阈值阈值在免疫功能低下人群中诊断结核感染

获取原文
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background. The detection of latent tuberculosis (TB) is essential for TB control, but T-cell assay might be influenced by degree of immunosuppression. The relationship between immunocompetence and interferon (IFN)-γresponse in QuantiFERON-TB Gold (QFT) is uncertain, especially in HIV-negative populations.Methods and Results. QFT has been performed for healthy subjects and TB suspected patients. Of 3017 patients, 727 were diagnosed as pulmonary TB by culture. The absolute number of blood lymphocyte in TB patients was significantly associated with QFT. Definitive TB patients were divided into eight groups according to lymphocyte counts. For each subgroup, receiver operating characteristic curve analysis was conducted from 357 healthy control subjects. The optimal cut-off for the patient group with adequate lymphocyte counts was found, but this was reduced for lymphocytopenia.Conclusions. The lymphocyte count was positively associated with QFT. Positive criteria should be calibrated in consideration of cell-mediated immunocompetence and risk of progression to active TB.
机译：背景。潜伏性结核（TB）的检测对于控制TB是必不可少的，但T细胞测定法可能会受到免疫抑制程度的影响。 QuantiFERON-TB Gold（QFT）中免疫能力与干扰素（IFN）-γ反应之间的关系尚不确定，尤其是在HIV阴性人群中。方法和结果。已对健康受试者和可疑结核病患者进行了QFT。通过培养，在3017名患者中，有727名被诊断为肺结核。结核病患者的淋巴细胞绝对数量与QFT显着相关。确定性结核病患者根据淋巴细胞计数分为八组。对于每个亚组，从357名健康对照受试者中进行了受试者工作特征曲线分析。找到了具有足够淋巴细胞计数的患者组的最佳临界值，但对于淋巴细胞减少症则有所降低。淋巴细胞计数与QFT呈正相关。考虑到细胞介导的免疫能力和发展为活动性结核病的风险，应校准阳性标准。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号