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首页> 外文期刊>Virulence. >Enhanced nasopharyngeal infection and shedding associated with an epidemic lineage of emm 3 group A Streptococcus
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Enhanced nasopharyngeal infection and shedding associated with an epidemic lineage of emm 3 group A Streptococcus

机译：与emm 3组A链球菌的流行谱系相关的增强的鼻咽感染和脱落

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ABSTRACT Background: A group A Streptococcus (GAS) lineage of genotype emm3, sequence type 15 (ST15) was associated with a 6 month upsurge in invasive GAS disease in the UK. The epidemic lineage (Lineage C) had lost 2 typical emm3 prophages, Φ315.1 and Φ315.2 associated with the superantigen ssa, but gained a different prophage (ΦUK-M3.1) associated with a different superantigen, speC and a DNAse spd1. Methods and Results: The presence of speC and spd1 in Lineage C ST15 strains enhanced both in vitro mitogenic and DNase activities over non-Lineage C ST15 strains. Invasive disease models in Galleria mellonella and SPEC-sensitive transgenic mice, revealed no difference in overall invasiveness of Lineage C ST15 strains compared with non-Lineage C ST15 strains, consistent with clinical and epidemiological analysis. Lineage C strains did however markedly prolong murine nasal infection with enhanced nasal and airborne shedding compared with non-Lineage C strains. Deletion of speC or spd1 in 2 Lineage C strains identified a possible role for spd1 in airborne shedding from the murine nasopharynx. Conclusions: Nasopharyngeal infection and shedding of Lineage C strains was enhanced compared with non-Lineage C strains and this was, in part, mediated by the gain of the DNase spd1 through prophage acquisition.
机译：摘要背景：基因型为emm3，序列类型15（ST15）的A组链球菌（GAS）血统与英国侵袭性GAS疾病的6个月高潮有关。流行谱系（C谱系）丢失了2种典型的与超级抗原ssa相关的emm3预噬菌体Φ315.1和Φ315.2，但获得了与不同的超级抗原speC和DNAse spd1相关的不同噬菌体（ΦUK-M3.1）。 。方法和结果：谱系C ST15菌株中speC和spd1的存在比非谱系C ST15菌株增强了体外有丝分裂和DNase活性。在Malleria mellonella和SPEC敏感的转基因小鼠中的侵袭性疾病模型显示，与非Lineage C ST15菌株相比，Lineage C ST15菌株的总体侵袭性没有差异，与临床和流行病学分析一致。然而，与非C系毒株相比，C系毒株确实显着延长了鼠鼻感染，并增强了鼻腔和空气传播的脱落。在2个谱系C菌株中speC或spd1的缺失确定了spd1在鼠鼻咽的空气传播中的可能作用。结论：与非谱系C菌株相比，谱系C菌株的鼻咽感染和脱落得到增强，这在一定程度上是由通过噬菌体获得获得的DNase spd1介导的。

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