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首页> 外文期刊>Veterinary research >Scrutinizing the triad of Vibrio tapetis , the skin barrier and pigmentation as determining factors in the development of skin ulcerations in wild common dab ( Limanda limanda )
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Scrutinizing the triad of Vibrio tapetis , the skin barrier and pigmentation as determining factors in the development of skin ulcerations in wild common dab ( Limanda limanda )

机译：仔细检查野生弧菌的三联体，皮肤屏障和色素沉着是野生普通民建民（Limanda limanda）皮肤溃疡发展的决定因素

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Recently, Vibrio tapetis was isolated for the first time from skin ulcerations in wild-caught common dab (Limanda limanda). To further examine its role in the development of these skin lesions, an in vivo experiment was performed. The significance of the skin barrier and in addition the difference between pigmented and non-pigmented side were investigated. Hence, the skin of common dab was treated in three different ways on both the pigmented and non-pigmented side. On a first “treatment zone”, the scales and overlying epidermal tissue were removed whereas in a second zone only the mucus was discarded. The third zone served as a non-treated zone. Thereafter, fish were challenged with V. tapetis. The control group was sham treated. Mortality, clinical signs, severity and size of the developing lesions were recorded. All animals were sacrificed and sampled 21?days post-inoculation. Significantly more fish of the group challenged with V. tapetis died compared to the control group with the highest incidence occurring 4?days post-inoculation. Fish challenged with V. tapetis developed more severe skin ulcerations. In zones where scales and epidermal tissue were removed, the ulcerations were more severe compared to zones where only mucus was eliminated. Ulcerations occurred more frequently, were more severe and larger on the pigmented side. Our data represents prove of V. tapetis as causative agent of ulcerative skin lesions although prior damage of the skin seems to be a major contributing factor. Furthermore, the pigmented side seemed predisposed to the development of skin ulcerations.
机译：最近，首次从野生的普通民用胶（Limanda limanda）的皮肤溃疡中分离到了弧菌。为了进一步检查其在这些皮肤损伤的发展中的作用，进行了体内实验。研究了皮肤屏障的重要性以及有色和无色面之间的差异。因此，在有色和无色侧均以三种不同的方式处理了普通民用轻工皮肤。在第一个“治疗区”，去除鳞屑和上皮表皮组织，而在第二个区，仅去除粘液。第三区用作未处理区。此后，用V. tapetis攻击鱼。对照组接受假手术治疗。记录发展中病变的死亡率，临床体征，严重程度和大小。接种后21天处死所有动物并取样。与对照组相比，接种V. tapetis的组死亡的鱼明显多于接种后4天发生率最高的对照组。用V. tapetis攻击的鱼发生了更严重的皮肤溃疡。与仅去除粘液的区域相比，在去除鳞屑和表皮组织的区域，溃疡更为严重。溃疡发生的频率更高，在色素沉着的一侧更严重并且更大。我们的数据证明了V. tapetis是溃疡性皮肤损伤的病因，尽管先前对皮肤的损害似乎是主要的影响因素。此外，色素沉着的一面似乎容易诱发皮肤溃疡。

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