Targeting TNF and TNF Receptor Pathway in HIV-1 Infection: from Immune Activation to Viral Reservoirs

Sébastien Pasquereau; Amit Kumar; Georges Herbein

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Targeting TNF and TNF Receptor Pathway in HIV-1 Infection: from Immune Activation to Viral Reservoirs

机译：针对HIV-1感染中的TNF和TNF受体途径：从免疫激活到病毒库

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Several cellular functions such as apoptosis, cellular proliferation, inflammation, and immune regulation involve the tumor necrosis factor-α (TNF)/TNF receptor (TNFR) pathway. Human immunodeficiency virus 1 (HIV-1) interacts with the TNF/TNFR pathway. The activation of the TNF/TNFR pathway impacts HIV-1 replication, and the TNF/TNFR pathway is the target of HIV-1 proteins. A hallmark of HIV-1 infection is immune activation and inflammation with increased levels of TNF in the plasma and the tissues. Therefore, the control of the TNF/TNFR pathway by new therapeutic approaches could participate in the control of immune activation and impact both viral replication and viral persistence. In this review, we will describe the intricate interplay between HIV-1 proteins and TNF/TNFR signaling and how TNF/TNFR activation modulates HIV-1 replication and discuss new therapeutic approaches, especially anti-TNF therapy, that could control this pathway and ultimately favor the clearance of infected cells to cure HIV-infected patients.

机译：细胞凋亡，细胞增殖，炎症和免疫调节等几种细胞功能涉及肿瘤坏死因子-α（TNF）/ TNF受体（TNFR）途径。人类免疫缺陷病毒1（HIV-1）与TNF / TNFR途径相互作用。 TNF / TNFR途径的激活会影响HIV-1复制，而TNF / TNFR途径是HIV-1蛋白的目标。 HIV-1感染的标志是免疫激活和炎症，血浆和组织中的TNF水平升高。因此，通过新的治疗方法控制TNF / TNFR途径可参与免疫激活的控制，并影响病毒复制和病毒持久性。在这篇综述中，我们将描述HIV-1蛋白与TNF / TNFR信号之间的复杂相互作用，以及TNF / TNFR激活如何调节HIV-1复制，并讨论可以控制该途径并最终控制新的治疗方法，尤其是抗TNF治疗有利于清除感染细胞以治愈HIV感染者。

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《Viruses》 |2017年第4期|共页
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Sébastien Pasquereau; Amit Kumar; Georges Herbein;
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中图分类微生物学;
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1. Cooperation of TNF Family Members CD40 Ligand, Receptor Activator of NF-κB Ligand, and TNF-α in the Activation of Dendritic Cells and the Expansion of Viral Specific CD8+ T Cell Memory Responses in HIV-1-Infected and HIV-1-Uninfected Individuals [J] . Qigui Yu, Jenny X. Gu, Colin Kovacs, The journal of immunology . 2003,第4期

机译：TNF家族成员CD40配体，NF-κB受体激活剂和TNF-α在树突状细胞的活化和病毒特异性CD8 + T细胞记忆应答在HIV-1感染者和HIV-1未感染者中的扩展合作
2. Activation of the extrinsic apoptotic pathway by TNF-alpha in human salivary gland (HSG) cells in vitro, suggests a role for the TNF receptor (TNF-R) and intercellular adhesion molecule-1 (ICAM-1) in Sjogren's syndrome-associated autoimmune sialadenitis. [J] . Wang Y, Shnyra A, Africa C Archives of Oral Biology . 2009,第11期

机译：TNF-α在人唾液腺（HSG）细胞中体外激活外在凋亡途径，提示TNF受体（TNF-R）和细胞间黏附分子1（ICAM-1）在干燥综合征相关的自身免疫中发挥作用si骨炎。
3. TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2 5-mediated activation of the noncanonical NF-κB pathway by TRAF-binding TNFRs [J] . Julia Hauer, Stephanie Pueschner, Parameswaran Ramakrishnan, Proceedings of the National Academy of Sciences of the United States of America . 2005,第8期

机译：TNF受体（TNFR）相关因子（TRAF）3用作TRAF2 5介导的TRAF结合TNFR激活非典型NF-κB途径的抑制剂
4. Analysis of Tissue Distribution of TNF-α, TNF-α-Receptors, and the Activating TNF-α-Converting Enzyme Suggests Activation of the TNF-α System in the Aging Intervertebral Disc [C] . BEATRICE E. BACHMEIER, ANDREAS G. NERLICH, CHRISTOPH WEILER, Meeting on Cell Signaling World: Signal Transduction Pathways as Therapeutic Targets . 2007

机译：肿瘤坏死因子-α，肿瘤坏死因子-α-受体和活化的肿瘤坏死因子-α转换酶的组织分布分析表明，在老化的椎间盘中肿瘤坏死因子-α系统的激活。
5. Tumor necrosis factor-alpha (TNFalpha) and receptor activator of NFkappaB ligand (RANKL) regulate osteoclast activity: Potential therapeutic targets in wear debris-induced osteolysis. [D] . Flick, Lisa Marie. 2002

机译：肿瘤坏死因子-α（TNFalpha）和NFkappaB配体的受体激活剂（RANKL）调节破骨细胞活性：磨损碎片诱导的骨溶解的潜在治疗靶标。
6. Targeting TNF and TNF Receptor Pathway in HIV-1 Infection: from Immune Activation to Viral Reservoirs [O] . Sébastien Pasquereau, Amit Kumar, Georges Herbein 2017

机译：针对TNF-1和TNF受体途径在HIV-1感染中的目标：从免疫激活到病毒库。
7. Targeting TNF and TNF Receptor Pathway in HIV-1 Infection: from Immune Activation to Viral Reservoirs [O] . Sébastien Pasquereau, Amit Kumar, Georges Herbein 2017

机译：针对HIV-1感染中的TNF和TNF受体途径：从免疫激活到病毒库

Targeting TNF and TNF Receptor Pathway in HIV-1 Infection: from Immune Activation to Viral Reservoirs

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