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Analysis of an Outbreak of Hemorrhagic Fever with Renal Syndrome in College Students in Xi’an, China

机译：西安市大学生肾综合征出血热暴发原因分析

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The aim of the present study was to analyze an outbreak of hemorrhagic fever with renal syndrome (HFRS), caused by a Hantavirus, in college students in the northern urban area of Xi’an in 2012. The outbreak affected six students and included two deaths. The epidemiological survey revealed that both of the deceased cases were misdiagnosed initially, and treatment was delayed. Furthermore, a higher rodent population density and lower HFRS vaccine coverage were observed in the affected area, which indicates a possible role in the outbreak. Rattus norvegicus (Rn) and Mus musculus (Mm) were the predominant host populations in the area. Genotyping revealed that all HVs from patients and rodents were Hantaan virus (HTNV). Sequence analysis of the S segments revealed that the HTNVs reported in this study had high similarity with strains reported in 2011 and 1985, but these viruses diverged from a strain isolated in 1984 and the HTNV prototype strain 76-118. Detection of anti-HV IgG and amplification of the S segment of HTNV from a non-natural HTNV reservoir indicates that further investigations by increased rodent trapping are necessary.
机译：本研究的目的是分析2012年西安市北部城市大学生因汉塔病毒引起的肾综合征出血热（HFRS）暴发。该暴发影响了6名学生，包括2例死亡。流行病学调查显示，两例死者最初都被误诊，治疗被推迟。此外，在受影响地区观察到更高的啮齿动物种群密度和更低的HFRS疫苗覆盖率，这表明可能在疫情爆发中发挥作用。褐家鼠（Rn）和小家鼠（Mm）是该地区的主要寄主种群。基因分型显示，来自患者和啮齿动物的所有HV均为汉坦病毒（HTNV）。对S片段的序列分析表明，该研究报告的HTNV与2011年和1985年报告的菌株具有高度相似性，但这些病毒与1984年分离的菌株和HTNV原型菌株76-118不同。从非天然HTNV储库中检测抗HV IgG并扩增HTNV的S片段表明，有必要通过增加啮齿类动物的捕获进行进一步研究。

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