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首页> 外文期刊>Virology Journal >First sero-prevalence of dengue fever specific immunoglobulin G antibodies in Western and North-Western provinces of Zambia: a population based cross sectional study
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First sero-prevalence of dengue fever specific immunoglobulin G antibodies in Western and North-Western provinces of Zambia: a population based cross sectional study

机译：赞比亚西部和西北省首例登革热特异性免疫球蛋白G抗体的血清流行：基于人群的横断面研究

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Background Dengue fever is a tropical infectious disease caused by dengue virus (DENV), a single positive-stranded RNA Flavivirus. There is no published evidence of dengue in Zambia. The objective of the study was to determine the sero-prevalence and correlates for dengue fever specific IgG antibodies in Western and North-Western provinces in Zambia. Methods A randomized cluster design was used to sample participants for yellow fever risk assessment. In order to rule out cross reactivity with other flaviviruses including dengue, differential antibody tests were done by ELISA. Data was processed using Epi Data version 3.1 and transferred to SPSS version 16.0 for analysis. Bivariate and multivariate analyses were performed to determine the association of dengue fever with various factors. Unadjusted odds ratios (OR), adjusted odds ratios (AOR) and their 95% confidence intervals (CI) are reported. Results A total of 3,624 persons were sampled for dengue virus infection of whom 53.3% were female and 23.9% were in the 5–14 years age group. Most persons in the survey attained at least primary education (47.6%). No significant association was observed between sex and dengue virus infection (p?=?1.000). Overall, 4.1% of the participants tested positive for Dengue IgG. In multivariate analysis, the association of age with Dengue infection showed that those below 5?years of age were 63% (AOR?=?0.37; 95% CI [0.16, 0.86]) less likely to be infected with Dengue virus compared to those aged 45?years or older. A significant association was observed between grass thatched roofing and Dengue infection (AOR?=?2.28; 95% CI [1.15, 4.53]) Respondents who used Insecticide Treated Nets (ITN) were 21% (AOR?=?1.21; 95% CI [1.01, 1.44]) more likely to be infected with dengue infection than those who did not use ITNs. Meanwhile, participants who visited Angola were 73% (AOR?=?1.73; 95% CI [1.27, 2.35]) more likely to be infected with Dengue virus than those who did not visit Angola. Conclusion This study provides the first evidence of dengue infection circulation in both North-Western and Western provinces of Zambia. It is important that surveillance activities for Dengue and diagnostic systems are expanded and strengthened, nationwide in order to capture information related to dengue virus and other flaviviruses.
机译：背景登革热是由登革热病毒（DENV）引起的一种热带传染病，登革热是一种正链RNA黄病毒。赞比亚尚无登革热的证据。这项研究的目的是确定赞比亚西部和西北省份的血清流行率和登革热特异性I​​gG抗体的相关性。方法采用随机聚类设计对参与者进行黄热病风险评估。为了排除与包括登革热在内的其他黄病毒的交叉反应，通过ELISA进行了差异抗体测试。使用3.1版Epi Data处理数据，并将其传输到SPSS 16.0版进行分析。进行了双因素和多因素分析，以确定登革热与各种因素的关系。报告了未调整的优势比（OR），已调整的优势比（AOR）及其95％置信区间（CI）。结果共有3,624人接受登革热病毒感染，其中5-14岁的女性为53.3％，23.9％。接受调查的大多数人至少接受过初等教育（47.6％）。在性别和登革热病毒感染之间未发现显着相关性（p = 1.000）。总体而言，有4.1％的参与者检测出登革热IgG阳性。在多变量分析中，年龄与登革热感染的相关性表明，与那些5岁以下的人相比，登革热病毒感染的可能性要低63％（AOR？=？0.37; 95％CI [0.16，0.86]）。年龄在45岁以上。茅草屋顶和登革热感染之间存在显着相关性（AOR≤2.28; 95％CI [1.15，4.53]）。使用杀虫剂处理过的蚊帐（ITN）的受访者为21％（AOR≤1.21; 95％CI）。 [1.01、1.44]）比未使用ITN的人更有可能感染登革热。同时，访问过安哥拉的参与者比未访问安哥拉的参与者感染登革热病毒的可能性高73％（AOR？=？1.73; 95％CI [1.27，2.35]）。结论本研究提供了赞比亚西北和西部省份登革热感染传播的第一个证据。重要的是，在全国范围内扩大和加强对登革热和诊断系统的监视活动，以便捕获与登革热病毒和其他黄病毒有关的信息。

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