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首页> 外文期刊>Virology reports >First study of complete genome of Dengue-3 virus from Rajasthan, India: genomic characterization, amino acid variations and phylogenetic analysis
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First study of complete genome of Dengue-3 virus from Rajasthan, India: genomic characterization, amino acid variations and phylogenetic analysis

机译：来自印度拉贾斯坦邦的登革3病毒完整基因组的首次研究：基因组表征，氨基酸变异和系统发育分析

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摘要

First study on the complete genome characterization of Dengue-3 virus is reported from dengue endemic state Rajasthan, India. The genome of 10,672 base pairs was studied with reference to global and the regional genomes of Dengue-3 virus. 388 variations were observed in the nucleotide sequences with reference to the NCBI genome, including 34 variations in the amino acids. Of these 34 AA variations, 4 variations showed AA substitution in Envelope proteins and 1 in Anchored capsid region. The remaining 29 variations were observed in amino acids constituting non structural (NS) proteins. The reported mutations, especially those leading to amino acid variations in non-structural proteins of virus may influence the clinical profile of patients and accuracy of ongoing diagnostic tests. Reported amino acid variations in virus envelope may influence the immune response of patients. Phylogenetic studies showed similarity of reported genome with genomes from India, Pakistan and China.
机译：印度登革热流行国拉贾斯坦邦报道了对登革3病毒完整基因组表征的首次研究。参照登革3病毒的全球和区域基因组研究了10,672个碱基对的基因组。参照NCBI基因组，在核苷酸序列中观察到388个变异，包括34个氨基酸变异。在这34个AA变异中，有4个变异显示信封蛋白中的AA取代和锚定衣壳区域中的1个。在构成非结构（NS）蛋白的氨基酸中观察到了其余29种变异。报道的突变，特别是那些导致病毒非结构蛋白氨基酸突变的突变，可能会影响患者的临床状况以及正在进行的诊断测试的准确性。报道的病毒包膜中的氨基酸变化可能影响患者的免疫反应。系统发育研究表明，报道的基因组与印度，巴基斯坦和中国的基因组相似。

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