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首页> 外文期刊>World Journal of AIDS >Survival of HIV Infected Children Born to Mothers Enrolled in a PMTCT Program in a Resource Poor Setting
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Survival of HIV Infected Children Born to Mothers Enrolled in a PMTCT Program in a Resource Poor Setting

机译：在资源匮乏的情况下，参加PMTCT计划的母亲所生的被HIV感染的儿童的生存

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Background: Pediatric HIV is a leading cause of morbidity and mortality worldwide. The substantial expansion in PMTCT has generated information on rates of transmission and associated factors, but there are limited studies on disease progression and mortality in vertically infected children, especially from resource poor settings. Methods: A birth cohort study was initiated in 2002 to focus on the role of a single dose of nevirapine in HIV transmission before Highly Active Antiretroviral Therapy (HAART) was readily available. The enrolment of women and subsequent follow up of the children occurred at 3 peri urban clinics around Harare. Findings: 479 women were HIV infected. From these, 93 (19%) children became HIV infected, 182 (38.0%) uninfected and 204 (43%) lost to follow up before HIV diagnosis. Of the HIV infected children, 40 (43%) died before the fifth birthday, 26 (28%) were lost to follow up and 27 (29%) were alive five years after maternal enrolment prior to availability of cART. Conclusion: In this setting, there was unacceptable high mortality from HIV infected children and loss to follow up prior to availability of HAART. A small proportion of HIV vertically infected children is surviving in resource poor settings without antiretroviral therapy.
机译：背景：儿科艾滋病毒是全世界发病率和死亡率的主要原因。 PMTCT的大幅扩展已经产生了有关传播率和相关因素的信息，但是有关垂直感染儿童，特别是资源贫乏地区儿童疾病进展和死亡率的研究很少。方法：2002年开始了一项出生队列研究，着眼于在高活性抗逆转录病毒疗法（HAART）可用之前，单剂量奈韦拉平在HIV传播中的作用。在哈拉雷附近的3个城市郊区诊所招收了妇女，随后对孩子进行了随访。调查结果：479名妇女感染了艾滋病毒。其中93名（19％）儿童感染了艾滋病毒，182名（38.0％）未感染儿童，而204名（43 %%）失去了在进行艾滋病毒诊断之前的随访工作。在感染了艾滋病毒的儿童中，有40名（43％）在五岁生日之前死亡，有26名（28％）失去随访，而有27名（29％）的母亲在加入cAR​​T之前五年就还活着。结论：在这种情况下，HIV感染儿童的高死亡率和无法接受HAART之前的随访损失令人难以接受。少数艾滋病毒垂直感染儿童在没有抗逆转录病毒疗法的情况下仍生活在资源贫乏的地区。

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