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首页> 外文期刊>World Journal of Oncology >Immunohistochemical Analysis of Cyclooxygenase-2 in Non-Melanocytic Skin Cancer: Correlation With Morphological Subtype and Histologic Grade
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Immunohistochemical Analysis of Cyclooxygenase-2 in Non-Melanocytic Skin Cancer: Correlation With Morphological Subtype and Histologic Grade

机译：非黑素细胞性皮肤癌中环氧合酶2的免疫组织化学分析：与形态亚型和组织学等级的关系

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Background: Basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) are known as non-melanoma skin cancers (NMSCs), and they account for approximately 90% of all skin cancers. Cyclooxygenase-2 (COX-2) is expressed in NMSC and in premalignant cutaneous lesions (actinic keratosis).Methods: Immunohistochemistry was performed with COX-2 antibodies in skin biopsies (paraffin tissue archival blocks) from 28 cases with SCC and 33 cases with BCC.Results: COX-2 was immunostained in a total of 61 cases. There was no staining or weakly positive staining in 73.8% of the cases (45 cases), and there was moderate or strong positive staining in 26.3% of the cases (16 cases). COX-2 was expressed in 42.4% of the BCC cases and in 57.1% of the SCC cases. There was a significant relationship between positive COX-2 staining and SCC (P = 0.016).Conclusions: In this study, SCCs were significantly correlated with the expression of COX-2. In addition, COX-2 was more frequently expressed in SCC than in BCC. The largest diameters of the SCC were significantly correlated with the expression of COX-2. There were no significant associations between COX-2 staining and clinicopathologic features such as the ulceration of the tumor, its anatomic localization, patient gender, the histologic grade of the SCC and the morphological subtype of the BCC.World J Oncol. 2014;5(5-6):189-195doi: http://dx.doi.org/10.14740/wjon869w
机译：背景：基底细胞癌（BCC）和鳞状细胞癌（SCC）被称为非黑素瘤皮肤癌（NMSC），它们约占所有皮肤癌的90％。方法：在28例SCC患者和33例SCC患者中，COX-2抗体在皮肤活检组织（石蜡组织档案阻滞）中进行了免疫组织化学分析，在NMSC和恶变前的皮肤病变（光化性角化病）中都有表达。结果：总共61例患者进行了COX-2免疫染色。在73.8％的病例（45例）中无染色或弱阳性染色，在26.3％的病例（16例）中有中度或强阳性染色。 COX-2在BCC病例中占42.4％，在SCC病例中占57.1％。结论COX-2阳性表达与SCC呈正相关（P = 0.016）。结论：SCC与COX-2表达密切相关。另外，COX-2在SCC中的表达比在BCC中更频繁。 SCC的最大直径与COX-2的表达显着相关。 COX-2染色与临床病理特征如肿瘤的溃疡，其解剖学定位，患者性别，SCC的组织学等级和BCC的形态学亚型之间无显着相关性。 2014; 5（5-6）：189-195doi：http：//dx.doi.org/10.14740/wjon869w

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