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首页> 外文期刊>World Journal of Oncology >Diagnostic Accuracy of Imaging Modalities in the Evaluation of Vascular Invasion in Pancreatic Adenocarcinoma: A Meta-Analysis
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Diagnostic Accuracy of Imaging Modalities in the Evaluation of Vascular Invasion in Pancreatic Adenocarcinoma: A Meta-Analysis

机译：成像方式在评估胰腺腺癌血管侵犯中的诊断准确性：一项荟萃分析

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Background: The extent of vascular invasion is a key factor determining the resectability of non-metastatic pancreatic adenocarcinoma. The purpose of this study is to determine the diagnostic accuracy of computed tomography (CT), endoscopic ultrasound (EUS), and magnetic resonance imaging (MRI) in the pre-operative evaluation of vascular invasion in pancreatic adenocarcinoma, with surgery as the reference standard. Methods: A search of the MEDLINE database for relevant articles in the English language published between January 2000 and February 2009 was performed. From each study, 2?× 2 tables were obtained, and pooled sensitivity, specificity, positive likelihood ratios, negative likelihood ratios and diagnostic odds ratios were calculated for each modality, along with a summary receiver operating characteristics (SROC) curve. Results: 16 studies with a total of 797 patients who had surgical assessment of vascular invasion were included in the analysis. Several studies evaluated more than one imaging modality, allowing 24 datasets to be obtained in total. Sensitivity was highest for CT (0.73, 95% CI 0.67 - 0.79), followed by EUS (0.66, 95% CI 0.56 - 0.75) and MRI (0.63, 95% CI 0.48 - 0.77). The specificity for all three imaging modalities was comparable. The diagnostic odds ratios for CT, EUS and MRI were 45.9 (95% CI 18.0 - 117.4), 23.0 (95%CI 9.4 - 56.6), 23.9 (95% CI 5.4 - 105.1) respectively. Conclusion: CT was more accurate than EUS and MRI in the evaluation of vascular invasion in pancreatic adenocarcinoma and should be the first line investigation in pre-operative staging.doi: http://dx.doi.org/10.4021/wjon657w
机译：背景：血管侵犯的程度是决定非转移性胰腺腺癌可切除性的关键因素。这项研究的目的是确定计算机断层扫描（CT），内窥镜超声（EUS）和磁共振成像（MRI）在胰腺腺癌的血管侵犯的术前评估中的诊断准确性，并以手术为参考标准。方法：在MEDLINE数据库中搜索2000年1月至2009年2月之间发布的英语相关文章。从每项研究中，获得2×2的表格，并为每种方式计算汇总的灵敏度，特异性，阳性似然比，阴性似然比和诊断比值比，以及汇总的接收者操作特征（SROC）曲线。结果：分析包括16项研究，共797例接受了血管侵犯手术评估的患者。几项研究评估了不止一种成像方式，总共可获得24个数据集。 CT的灵敏度最高（0.73，95％CI 0.67-0.79），其次是EUS（0.66，95％CI 0.56-0.75）和MRI（0.63，95％CI 0.48-0.77）。所有三种成像方式的特异性是可比较的。 CT，EUS和MRI的诊断优势比分别为45.9（95％CI 18.0-117.4），23.0（95％CI 9.4-56.6），23.9（95％CI 5.4-105.1）。结论：CT在评价胰腺癌血管侵犯方面比EUS和MRI更为准确，应作为术前分期的一线研究。doi：http://dx.doi.org/10.4021/wjon657w

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