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首页> 外文期刊>World Journal of Oncology >New Considerations in the Design of Clinical Trials for Bone Metastases
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New Considerations in the Design of Clinical Trials for Bone Metastases

机译：骨转移癌临床试验设计的新思路

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Palliative radiotherapy (RT) is prescribed to patients with bone metastases to alleviate symptoms and improve quality of life. The lack of consistent endpoints for such trials has made cross study comparison difficult and has led to contradictory conclusions. The International Bone Metastases Consensus Working Party was established to create a standard set of endpoints and recommendations for future clinical trials. Recommendations were included regarding eligibility criteria, pain assessments, follow-up assessments, timing, as well as radiation techniques. Suggestions were also made to facilitate the ease with which different studies could be compared as well as to encourage widespread consistency in certain aspects of trial design. Investigators conducting clinical trials in bone metastases should continue to adopt these recommendations to ensure consistent guidelines based on the most recent literature. doi:10.4021/wjon445w
机译：患有骨转移的患者可采用姑息放疗（RT），以减轻症状并改善生活质量。此类试验缺乏一致的终点，这使得交叉研究比较变得困难，并得出了相互矛盾的结论。成立了国际骨转移共识工作组，以创建一组标准的终点和建议，以供将来的临床试验之用。关于资格标准，疼痛评估，随访评估，时间安排以及放射技术的建议也包括在内。还提出了一些建议，以简化与不同研究的比较，并鼓励在试验设计的某些方面保持广泛的一致性。在骨转移方面进行临床试验的研究人员应继续采用这些建议，以确保基于最新文献的指导方针一致。 doi：10.4021 / wjon445w

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