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首页> 外文期刊>World Journal of Surgical Oncology >Clinical features and hypoxic marker expression of primary sinonasal and laryngeal small-cell neuroendocrine carcinoma: a small case series
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Clinical features and hypoxic marker expression of primary sinonasal and laryngeal small-cell neuroendocrine carcinoma: a small case series

机译：小病例系列原发性鼻鼻咽喉小细胞神经内分泌癌的临床特征和低氧标志物表达

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Background Small-cell neuroendocrine carcinoma (SCNEC) of the head and neck is rare. The prognosis of SCNEC in the nasal cavity and larynx is poor. The aim of this study was to investigate the clinicopathological features of nasal and laryngeal SCNEC and to determine the expression of HIF-1α, GLUT-1, PI3K, and p-Akt in SCNEC. Methods Between 2003 and 2012, 10 consecutive patients with histologically demonstrated nasal and laryngeal SCNEC were enrolled. Clinicopathological materials and follow-up data were analyzed retrospectively. Immunohistochemistry was used to detect GLUT-1, HIF-1α, PI3K, and p-Akt expression in paraffin wax-embedded tumor specimens. Results The subjects were eight males and two females with a mean age of 60.8 (range: 53 to 71) years. Tumors were located in the maxillary sinus (n?=?3) and larynx (n?=?7). At last follow-up, four patients (40.0%) had local recurrence and five patients (50.0%) had developed distant metastases. Six patients died. The mean overall survival was 19.3?±?2.1?months. Expression of GLUT-1, HIF-1α, PI3K, and p-Akt was seen in sinonasal and laryngeal SCNEC in 80 (8 out of 10), 50 (5 out of 10), 40 (4 out of 10), and 40% (4 out of 10) of cases, respectively. Expression of GLUT-1, HIF-1α, PI3K, and p-Akt was higher in sinonasal and laryngeal SCNEC than in precancerous lesions. Conclusions Primary sinonasal and laryngeal SCNEC is rare. This paper presents 10 cases of sinonasal and laryngeal SCNEC with more common local recurrence and distant metastasis. HIF-1α, GLUT-1, PI3K, and p-Akt expression was higher in sinonasal and laryngeal SCNEC than in precancerous lesions.
机译：背景技术头部和颈部的小细胞神经内分泌癌（SCNEC）很少见。 SCNEC在鼻腔和喉中的预后较差。这项研究的目的是调查鼻和喉SCNEC的临床病理特征，并确定HCN-1α，GLUT-1，PI3K和p-Akt在SCNEC中的表达。方法2003年至2012年间，连续10例经组织学证实为鼻和喉SCNEC的患者入组。回顾性分析临床病理资料和随访资料。免疫组织化学用于检测石蜡包埋的肿瘤标本中的GLUT-1，HIF-1α，PI3K和p-Akt表达。结果受试者为八名男性和两名女性，平均年龄为60.8岁（范围：53至71）。肿瘤位于上颌窦（n == 3）和喉部（n == 7）。在最后一次随访中，四名患者（40.0％）发生局部复发，五名患者（50.0％）发生远处转移。 6例患者死亡。平均总生存期为19.3±2.1个月。 GLUT-1，HIF-1α，PI3K和p-Akt的表达在鼻窦和喉SCNEC中分别有80（10中的8），50（10中的5），40（10中的4）和40（40）表达％（10分之4）的情况。鼻窦和喉SCNEC中GLUT-1，HIF-1α，PI3K和p-Akt的表达高于癌前病变。结论原发性鼻窦和喉SCNEC少见。本文介绍了10例鼻窦和喉SCNEC病例，这些病例多见于局部复发和远处转移。鼻窦和喉SCNEC中的HIF-1α，GLUT-1，PI3K和p-Akt表达高于癌前病变。

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