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首页> 外文期刊>World Journal of Vaccines >T Regulatory Cells and BCG as a Vaccine against Tuberculosis: An Overview
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T Regulatory Cells and BCG as a Vaccine against Tuberculosis: An Overview

机译：T调节细胞和卡介苗作为抗结核疫苗：概述

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摘要

Bacille Calmette Guerin (BCG), which has been used since 1921 as the only vaccine against tuber-culosis (TB), protects poorly, if at all, against pulmonary tuberculosis among adults in high incident developing countries. This failure has been attributed to the possible down modulating action of T regulatory cells (Tregs), which can be stimulated by environmental mycobacteria and expanded by BCG vaccination. Tregs induced at the site of BCG vaccination may interfere with protection against tuberculosis. This communication describes the contribution of Tregs towards dampening the efficacy of BCG and plausible approaches to countering this down modulating effect of Tregs. Probably, antigen specific inhibition of the local recruitment of Tregs whilst avoiding generalised disturbance of immune homeostasis could prove to be worthwhile. Alternatively, drugs with short half life may achieve more acceptable transient inhibition of Tregs function than the prolonged action of monoclonal antibodies. Evolving novel safe strategies is a challenge for developing a better anti TB vaccine.
机译：Bacille Calmette Guerin（BCG）自1921年以来就一直用作抗结核病（TB）的唯一疫苗，但在发生率高的发展中国家，成年人的肺结核病防护不力，甚至根本不能抵抗。该失败归因于T调节细胞（Tregs）可能的下调作用，其可被环境分枝杆菌刺激并通过卡介苗接种扩大。在BCG疫苗接种部位诱导的Treg可能会干扰对结核病的保护。该交流描述了Tregs对抑制BCG功效的贡献以及对抗Tregs这种下调作用的合理方法。可能，抗原特异性抑制Treg的局部募集同时避免免疫稳态的普遍干扰可能是值得的。或者，半衰期短的药物可能会比单克隆抗体的延长作用获得更可接受的Tregs瞬时抑制作用。不断发展的新型安全策略是开发更好的抗结核疫苗的挑战。

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