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首页> 外文期刊>World Journal of Oncology >Sentinel Lymph Node Biopsy in Patients With Thick Primary Cutaneous Melanoma
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Sentinel Lymph Node Biopsy in Patients With Thick Primary Cutaneous Melanoma

机译：厚原发性皮肤黑色素瘤患者前哨淋巴结活检

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Background: The clinical value of sentinel lymph node biopsy (SLNB) in patients with thick melanoma is uncertain. The purpose of this study was to investigate the correlations between survival and lymph node status in thick melanomas. Methods: Of a total of 736 melanoma patients registered between 2000 and 2016, 50 presented with thick melanomas (≥ 4.0 mm) without distant metastatic disease. All patients were examined with a whole-body magnetic resonance imaging, or computed tomography, and positron emission tomography-computed tomography depending on the incorporation of the new technology in our medical institutions. They were studied according to the following procedure: 1) preoperative determination of regional lymph node along with the estimation and localization of sentinel lymph node (SLN) (dynamic isotope lymphography); 2) intraoperative localization and SLNB (lymphatic mapping); and 3) histopathology. Patient and tumor features were collected. Results: Mean follow-up was 40 months, and 37% had a follow-up ≥ 5 years. A positive SLN was identified in 28 patients (56%). No significant difference in melanoma-specific overall survival was observed in terms of the primary tumor site. Hazard ratios (HRs) were statistically significant for SLNB-positive group and mitotic rate (MR) 3 mmsup2/sup, but not for presence of ulceration. Mortality risk in the SLN-positive group was almost fourfold greater than that in the SLN-negative group at any time of follow-up. Conclusions: SLN status, along with MR, can provide valuable prognostic information in patients with thick primary cutaneous melanoma.
机译：背景：前哨淋巴结活检（SLNB）在厚性黑色素瘤患者中的临床价值尚不确定。这项研究的目的是调查厚黑色素瘤的生存率与淋巴结状态之间的相关性。方法：在2000年至2016年之间登记的736名黑色素瘤患者中，有50例表现为无远处转移性疾病的厚黑色素瘤（≥4.0 mm）。所有患者均经过全身磁共振成像或计算机断层扫描，以及正电子发射断层扫描-计算机断层扫描，具体取决于新技术在我们医疗机构中的应用。根据以下步骤进行研究：1）术前确定区域淋巴结，并评估和定位前哨淋巴结（SLN）（动态同位素淋巴照相）; 2）术中定位和SLNB（淋巴标测）; 3）组织病理学。收集患者和肿瘤特征。结果：平均随访时间为40个月，有37％的随访时间≥5年。在28例患者（56％）中发现SLN阳性。就原发肿瘤部位而言，黑色素瘤特异性总体生存率无显着差异。 SLNB阳性组和有丝分裂率（MR）> 3 mm 2 的危险比（HRs）均具有统计学意义，但对于溃疡的发生则没有统计学意义。在随访中，SLN阳性组的死亡率风险几乎比SLN阴性组的死亡率高四倍。结论：SLN状态和MR可以为原发性皮肤黑色素瘤较厚的患者提供有价值的预后信息。

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