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首页> 外文期刊>Haematologica >The sensitivity of CD138 immunostaining of bone marrow trephine specimens for quantifying marrow involvement in MGUS and myeloma, including samples with a low percentage of plasma cells | Haematologica
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The sensitivity of CD138 immunostaining of bone marrow trephine specimens for quantifying marrow involvement in MGUS and myeloma, including samples with a low percentage of plasma cells | Haematologica

机译：骨髓冰毒标本CD138免疫染色对MGUS和骨髓瘤（包括浆细胞百分比低的样本）的累及定量的敏感性|血液学

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摘要

Accurate quantification of plasma cells in bone marrow samples is essential for the diagnosis, classification and prognosis of plasma-cell dyscrasias. Published comparisons between aspirate/trephine morphology, flow cytometry and immunohistochemistry are lacking. Bone marrow plasma cells from 100 patients with plasma cell myeloma or monoclonal gammopathy of undetermined significance were quantified by a 500-cell differential count on Romanowsky-stained aspirate slides, flow-cytometry gating of CD38bright+/CD138+ cells, hematoxylin and eosin trephine section examination and CD138 trephine immunohistology. The results of quantification by the different methods were compared. Compared to other methods, CD138 trephine immunohistology consistently demonstrated greater plasma-cell infiltration. Immunohistology is the most sensitive method for assessment of plasma-cell infiltration at diagnosis or post-therapy, especially in patients with minimal bone marrow involvement.
机译：骨髓样本中浆细胞的准确定量对于浆细胞发育不良的诊断，分类和预后至关重要。尚缺乏关于抽吸液/三氢吗啡形态，流式细胞仪和免疫组织化学之间已发表的比较结果。通过在Romanowsky染色的吸出玻片上进行500个细胞的计数，CD38bright + / CD138 +细胞的流式细胞术门控，苏木精和曙红的肌钙蛋白切片检查，并对100例血浆浆细胞性骨髓瘤或单克隆丙种球蛋白病患者的骨髓浆细胞进行定量，其数量未定。 CD138钙华免疫组织学。比较了不同方法的定量结果。与其他方法相比，CD138钙华蛋白免疫组织学始终显示出更大的浆细胞浸润。免疫组织学是评估诊断或治疗后浆细胞浸润的最灵敏方法，尤其是在骨髓受累最少的患者中。

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