...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Yonsei Medical Journal >Hypoxia Delays the Intracellular Ca2+ Clearance by Na+ - Ca2+ Exchanger in Human Adult Cardiac Myocytes
【24h】

Hypoxia Delays the Intracellular Ca2+ Clearance by Na+ - Ca2+ Exchanger in Human Adult Cardiac Myocytes

机译：低氧延迟了成人心肌细胞中Na +-Ca2 +交换剂的细胞内Ca2 +清除。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Transient myocardial ischemia during cardiac surgery causes a loss of energy sources, contractile depression, and accumulation of metabolites and H+ ion resulting in intracellular acidosis. The reperfusion following ischemic cardioplegia recovers intracellular pH, activates Na+-H+ exchange and Na+-Ca2+ exchange transports and consequently produces Ca2+ overload, which yields cell death. Among the various Ca2+ entry pathways, the Na+-Ca2+ exchanger is known to play one of the major roles during the ischemia/reperfusion of cardioplegia. Consequently, information on the changes in intracellular Ca2+ activities of human cardiac myocytes via the Na+-Ca2+ exchanger is imperative despite previous measurements of Ca2+ current of human single myocytes. In this study, human single myocytes were isolated from the cardiac tissues obtained during open-heart surgery and intracellular Ca2+ activity was measured with cellular imaging techniques employing fluorescent dyes. We report that the Na+-Ca2+ exchanger of adult cardiac myocytes is more susceptible to hypoxic insult than that of young patients.
机译：心脏手术中的短暂性心肌缺血会导致能量损失，收缩性抑郁以及代谢物和H + 离子的积累，从而导致细胞内酸中毒。缺血性心脏停搏后的再灌注恢复细胞内pH，激活Na + -H + 交换和Na + -Ca 2 + 交换运输，因此产生Ca 2 + 超载，从而导致细胞死亡。在各种Ca 2 + 进入途径中，Na + -Ca 2 + 交换子在局部缺血过程中起主要作用之一。 /心脏停搏再灌注。因此，尽管有先前的研究，通过Na + -Ca 2 + 交换子对人心肌细胞内Ca 2 + 活性变化的信息仍然是必不可少的。单个肌细胞Ca 2 + 电流的测量在这项研究中，从心脏直视手术中获得的心脏组织中分离出人类单个心肌细胞，并使用荧光染料通过细胞成像技术测量了细胞内Ca 2 + 活性。我们报告说，成年心肌细胞的Na + -Ca 2 + 交换子比年轻患者更容易发生缺氧损伤。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号