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首页> 外文期刊>Yonsei Medical Journal >Sonic Hedgehog Pathway as the Prognostic Marker in Patients with Extensive Stage Small Cell Lung Cancer
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Sonic Hedgehog Pathway as the Prognostic Marker in Patients with Extensive Stage Small Cell Lung Cancer

机译：声波刺猬通路作为广泛期小细胞肺癌患者的预后标志

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Purpose Sonic hedgehog (Shh) signaling pathway is known to play a crucial role in carcinogenesis in various malignancies, including lung cancer regarding tumorigenesis, angiogenesis, and cellular differentiation. The aim of this study was to investigate the value of components of Shh pathway as a prognostic marker in extensive stage small cell lung cancer (ES-SCLC) patients. Materials and Methods We retrospectively analyzed data of 36 patients who were diagnosed with ES-SCLC between 2008 and 2012 at a single center. We performed immuo-histochemistry for glioma-associated oncogene homolog zinc finger protein 1 (Gli1), patched, Shh, and Ptch-mediated repression of smoothened (Smo) proteins using formalin-fixed, paraffin-embedded tissue derived from primary tumors. We then conducted survival analysis to evaluate the prognostic impact of these markers. Results All 36 patients received platinum-based doublet chemotherapy. The median progression free survival and median overall survival were 6.9 months [95% confidence interval (CI), 6.5–7.3] and 11.7 months (95% CI, 9.1–14.3), respectively. The overall response rate was 84%. Of the 36 tissue specimens examined, over-expression of Gli1, Patched, Shh, and Smo was found in 12 (33.3%), five (13.9%), five (13.9%), and six (16.7%) cases, respectively. We found that high expression of Shh was associated with worse progression free survival (6.3 vs. 7.6 months, p =0.005) and overall survival (9.2 vs. 12.0 months, p =0.039) by both univariate and multivariate analyses, whereas other markers were not related to patient prognosis. Conclusion A high proportion of small cell lung cancer tumors express proteins related to Shh pathway, and over-expression of Shh is correlated with poor prognosis.
机译：目的音速刺猬（Shh）信号传导途径在各种恶性肿瘤的致癌作用中都起着至关重要的作用，包括关于肿瘤发生，血管生成和细胞分化的肺癌。这项研究的目的是调查Shh通路的成分作为广泛期小细胞肺癌（ES-SCLC）患者的预后指标的价值。材料和方法我们回顾性分析了2008年至2012年之间在单个中心诊断为ES-SCLC的36例患者的数据。我们使用源自原发肿瘤的福尔马林固定，石蜡包埋的组织，对神经胶质瘤相关癌基因同源锌指蛋白1（Gli1），修补的，Shh和Ptch介导的平滑化（Smo）蛋白进行了免疫组化分析。然后，我们进行了生存分析，以评估这些标志物的预后影响。结果全部36例患者均接受了铂类双线化疗。中位无进展生存期和中位总生存期分别为6.9个月[95％置信区间（CI），6.5-7.3]和11.7个月（95％CI，9.1-14.3）。总体回应率为84％。在检查的36个组织样本中，分别在12（33.3％），5（13.9％），5（13.9％）和6（16.7％）例中发现了Gli1，Patched，Shh和Smo的过度表达。我们发现，通过单因素和多因素分析，Shh的高表达与较差的无进展生存期（6.3 vs. 7.6个月，p = 0.005）和总生存期（9.2 vs. 12.0个月，p = 0.039）相关，而其他标记是与患者的预后无关。结论小细胞肺癌中大量表达与Shh通路相关的蛋白，而Shh的过表达与预后不良有关。

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