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首页> 外文期刊>Hematology/Oncology and Stem Cell Therapy >Brain infarction and blasts with bilobed nuclei in a patient with monocytic acute myeloid leukemia mimicking acute promyelocytic leukemia
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Brain infarction and blasts with bilobed nuclei in a patient with monocytic acute myeloid leukemia mimicking acute promyelocytic leukemia

机译：模拟急性早幼粒细胞白血病的单核细胞急性髓性白血病患者的脑梗死和双叶核爆炸

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We are presenting a case of an adult male patient with monocytic acute myeloid leukemia (AML) who had on presentation brain infarction and bilobed nuclei had been demonstrated in many of the leukemic blasts. There was no laboratory evidence of acute disseminated intravascular coagulopathy, on presentation or later on. Initially the diagnosis of acute promyelocytic leukemia (APL) was considered, so all trans-retinoic acid (ATRA) was added to induction chemo therapy. As the diagnosis of APL was ruled out, based on the flow cytometry, fluorescent in situ hybridization and polymerase chain reaction findings, the ATRA was discontinued and the patient continued on the standard AML chemo therapy induction regimen. Later on chromosomal analysis was also normal. Sever dehydration on presentation, would have contributed to brain infarction. AML particularly monocytic, can mimic APL, especially its microgranular variant. The possible ATRA therapy side effects, can be avoided by early confirmation of the diagnosis.
机译：我们正在介绍一例患有单核细胞急性髓性白血病（AML）的成年男性患者，该患者在许多白血病母细胞中均表现出脑梗死和双叶核。在就诊时或以后，没有实验室证据表明急性弥散性血管内凝血病。最初考虑诊断急性早幼粒细胞白血病（APL），因此将所有反式维甲酸（ATRA）添加到诱导化学疗法中。根据流式细胞术，荧光原位杂交和聚合酶链反应的发现，排除了APL的诊断，因此终止了ATRA，患者继续采用标准的AML化学疗法诱导方案。后来进行染色体分析也很正常。呈现时严重脱水，将加剧脑梗塞。 AML特别是单核细胞，可以模仿APL，尤其是其微颗粒变体。尽早确认诊断可以避免可能的ATRA治疗副作用。

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