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Management of Tumour Lysis Syndrome in Non-Hodgkin Lymphoma

机译:非霍奇金淋巴瘤的肿瘤溶解综合征的管理

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Tumour lysis syndrome is an oncological emergency and non-Hodgkin lymphoma is one of the high risk groups to develop this complication before or during chemotherapy. This article provides an overview and evaluates the role of urate oxidase in management of this condition. Retrospective review of forty-four cases in our hospital showed that four patients (9%) developed grade 3 to grade 4 tumour lysis syndrome and two of them required renal replacement therapy. All of them recovered from this acute complication after vigorous supportive therapy. Burkitt's lymphoma with intra-abdominal presentation and huge tumour load with multiple sites involvement are the main risk factors for development of tumour lysis syndrome.
机译:肿瘤溶解综合征是一种肿瘤急症,非霍奇金淋巴瘤是在化疗之前或期间发生这种并发症的高危人群之一。本文提供了概述,并评估了尿酸氧化酶在这种情况的管理中的作用。回顾性分析我院四十四例患者,其中四例(9%)发展为3至4级肿瘤溶解综合征,其中两名需要肾脏替代治疗。大力支持治疗后,所有人均从这种急性并发症中康复。腹腔内表现的伯基特淋巴瘤和累及多个部位的巨大肿瘤负荷是肿瘤溶解综合征发展的主要危险因素。

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