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首页> 外文期刊>Hong Kong journal of emergency medicine. >Comparison of the Efficacies of Topical Anaesthetics in the Reduction of the Pain during Peripheral Intravenous Cannulation: A Randomised Trial
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Comparison of the Efficacies of Topical Anaesthetics in the Reduction of the Pain during Peripheral Intravenous Cannulation: A Randomised Trial

机译：局部麻醉药在减少周围静脉插管过程中疼痛中的功效比较：一项随机试验

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This study aimed to compare the efficacies of two different topical anesthetic agents and placebo in the reduction of the pain observed during intravenous (IV) cannulation. Study enrolled a total of 129 healthy male donors and IV cannulation was performed to antecubital region. The donors were assigned into three groups. Prilocaine-lidocaine mixture cream (E), lidocaine spray (X) and Placebo cream (P) were given to patients. After the administration the donors were waited for approximately 45 minutes. The pain experienced by the donors after the insertion of 16 gauge cannula in arms was recorded as “pain experienced at minute 0, 5 and 15” on 100 mm visual analog scale (VAS). In the first group, there was no significant difference between mean VAS scores recorded after the administration of prilocainelidocaine mixture cream and lidocaine spray before IV cannulation. Mean VAS value was 9.1 mm with prilocaine-lidocaine mixture cream and 9.3 mm with lidocaine spray. In the second group, we detected significant difference between mean VAS scores recorded after the administration of lidocaine spray and placebo cream. Mean VAS value was 9.8 mm with lidocaine spray and 24.3 mm with placebo (p<0.05). In the third group, we found statistically significant difference between VAS scores recorded after the administration of prilocaine-lidocaine mixture cream and placebo cream. Mean VAS value was 8.8 mm with prilocaine-lidocaine mixture cream and 33.0 mm with placebo cream (p<0.05). Although both agents administrated before IV cannulation were superior to placebo in adult patients in this study, we can state that these drugs were not superior to each other and showed similar efficacy.
机译：这项研究旨在比较两种不同的局部麻醉药和安慰剂在减轻静脉（IV）插管过程中观察到的疼痛中的功效。研究共纳入129名健康男性捐献者，并对肘前区域进行了静脉插管。捐助者分为三组。给予患者普利卡因-利多卡因混合霜（E），利多卡因喷雾剂（X）和安慰剂霜（P）。给药后，供体等待约45分钟。在100 mm视觉模拟量表（VAS）上，将16个规格的套管插入手臂后，供体经历的疼痛记录为“在0、5和15分钟时经历的疼痛”。在第一组中，在静脉插管之前服用丙胺卡因利多卡因混合乳膏和利多卡因喷雾剂后，记录的平均VAS评分之间没有显着差异。丙胺卡因-利多卡因混合乳膏的VAS平均值为9.1毫米，利多卡因喷雾剂的平均VAS值为9.3毫米。在第二组中，我们发现利多卡因喷雾剂和安慰剂乳膏给药后记录的平均VAS评分之间存在显着差异。利多卡因喷雾剂的平均VAS值为9.8毫米，安慰剂为24.3毫米（p <0.05）。在第三组中，我们发现在使用丙胺卡因-利多卡因混合乳膏和安慰剂乳膏后记录的VAS评分之间存在统计学差异。丙胺卡因-利多卡因混合乳膏的平均VAS值为8.8毫米，安慰剂乳膏的平均VAS值为33.0毫米（p <0.05）。尽管在本研究中，在静脉内插管之前使用的两种药物在成年患者中均优于安慰剂，但我们可以指出，这两种药物彼此之间并不优于并且显示出相似的疗效。

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